Contribution of platelets to tumour metastasis.
TLDR
Contributions of platelets to tumour cell survival and spread suggest platelets as a new avenue for therapy.Abstract:
Experimental evidence suggests that platelets contribute to metastasis through adhesive and haemostatic functions that promote cancer cell survival, immune evasion and interactions with vascular cells to assist organ colonization from the bloodstream. Extensive experimental evidence shows that platelets support tumour metastasis. The activation of platelets and the coagulation system have a crucial role in the progression of cancer. Within the circulatory system, platelets guard tumour cells from immune elimination and promote their arrest at the endothelium, supporting the establishment of secondary lesions. These contributions of platelets to tumour cell survival and spread suggest platelets as a new avenue for therapy.read more
Citations
More filters
Journal ArticleDOI
Phosphatidylinositol 3 monophosphate metabolizing enzymes in blood platelet production and in thrombosis
Marie Bellio,Manuella Caux,Alicia Vauclard,Gaëtan Chicanne,Marie-Pierre Gratacap,Anne-Dominique Terrisse,Sonia Severin,Bernard Payrastre +7 more
TL;DR: The role of PtdIns3P metabolizing enzymes in platelet production and function is discussed and potential new anti-thrombotic therapeutic perspectives based on inhibitors targeting specifically Ptd Insurance 3 monophosphate metabolize enzymes will be commented.
Journal ArticleDOI
Breast cancer stem-like cells can promote metastasis by activating platelets and down-regulating antitumor activity of natural killer cells.
Wang Shuo,Wang Shuo,Zhang Ying,Cong Wei-hong,Liu Jie,Zhang Yuren,Fan Huiting,Xu Yonggang,Lin Hongsheng +8 more
TL;DR: Findings indicate that CSCs could efficiently activate platelets, induce platelets to secrete more TGF-β1, decrease NKG2D expression and inhibit antitumor activity of NK cell, compared with 4T1.
Journal ArticleDOI
Platelet transfusion in thrombocytopenic cancer patients: Sometimes justified but likely insidious.
TL;DR: Until any randomized controlled trials can objectively document their effects on survival or cancer recurrence, minimizing the use of platelet transfusion in cancer patients appears to represent a reasonable precautionary measure.
Journal ArticleDOI
Analysis of Multimerin 1 (MMRN1) expression in ovarian cancer.
Abhinav Saini,Kumari Binita Chandra,V.L Kumar,Sandeep Mathur,Jai Bhagwan Sharma,Sunesh Kumar,Savita Yadav +6 more
TL;DR: MMRN1 expression is associated with EOC progression and MMRN1 may be potential biomarker candidates for early-stage EOC detection however further experiments are required in a large cohort to establish this proposition and saliva can be explored as a novel medium for ovarian cancer diagnosis.
Journal ArticleDOI
Small Ones to Fight a Big Problem-Intervention of Cancer Metastasis by Small Molecules.
Dennis Kobelt,Mathias Dahlmann,Malti Dumbani,Nazli Güllü,Benedikt Kortüm,Miguel E. Alberto Vilchez,Ulrike Stein,Wolfgang Walther +7 more
TL;DR: Key biological steps of the metastatic cascade, such as cell dissemination, migration and invasion as well as the action of metastasis suppressors are defined and targeted with tailored therapeutic strategies of intervention or even prevention using a wide range of small molecules are discussed.
References
More filters
Journal ArticleDOI
Tumor Angiogenesis: Therapeutic Implications
TL;DR: This new capillary growth is even more vigorous and continuous than a similar outgrowth of capillary sprouts observed in 2016 and is likely to be accompanied by neovascularization.
Journal ArticleDOI
Cancer Metastasis: Building a Framework
Gaorav P. Gupta,Joan Massagué +1 more
TL;DR: Understanding of the origins and nature of cancer metastasis and the selection of traits that are advantageous to cancer cells is promoted.
Journal ArticleDOI
Dissemination and growth of cancer cells in metastatic sites
TL;DR: Inhibition of the growth of metastases in secondary sites offers a promising approach for cancer therapy and could help to improve the treatment of metastatic disease.
Journal ArticleDOI
Microenvironmental regulation of metastasis
TL;DR: Experimental data demonstrating the role of the microenvironment in metastasis is described, areas for future research are identified and possible new therapeutic avenues are suggested.
Journal ArticleDOI
Integrins in cancer: biological implications and therapeutic opportunities
TL;DR: Clinical developments emphasize the need to identify how integrin antagonists influence the tumour and its microenvironment.