Contribution of platelets to tumour metastasis.
TLDR
Contributions of platelets to tumour cell survival and spread suggest platelets as a new avenue for therapy.Abstract:
Experimental evidence suggests that platelets contribute to metastasis through adhesive and haemostatic functions that promote cancer cell survival, immune evasion and interactions with vascular cells to assist organ colonization from the bloodstream. Extensive experimental evidence shows that platelets support tumour metastasis. The activation of platelets and the coagulation system have a crucial role in the progression of cancer. Within the circulatory system, platelets guard tumour cells from immune elimination and promote their arrest at the endothelium, supporting the establishment of secondary lesions. These contributions of platelets to tumour cell survival and spread suggest platelets as a new avenue for therapy.read more
Citations
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Journal ArticleDOI
Timing of Aspirin Use Among Patients With Colorectal Cancer in Relation to Mortality: A Systematic Review and Meta-Analysis.
TL;DR: Continued aspirin use before and after CRC diagnosis has the most advantage regarding the improvement of CRC mortality, and further prospective trials and mechanistic studies are highly warranted.
Journal ArticleDOI
Integrative diagnosis of cancer by combining CTCs and associated peripheral blood cells in liquid biopsy
TL;DR: An integrative analysis of CTCs and associated peripheral blood cells should be advocated for, which could provide a novel insight into tumor biology and offer comprehensive information in cancer diagnosis, prognosis, and therapy efficacy evaluation.
Patent
Platelet membrane-coated drug delivery system
Zhen Gu,Quanyin Hu +1 more
TL;DR: In this article, a platelet membrane-coated nanovehicle is described, and a method for treating vascular disease in a subject that involves administering to the subject an injection of platelet proteins capable of interacting with cancer cells.
Journal ArticleDOI
Evaluation of prognostic factors after primary chemoradiotherapy of anal cancer: A multicenter study of the German Cancer Consortium - Radiation Oncology Group (DKTK-ROG).
D. Martin,Teresa Schreckenbach,Peter G. Ziegler,Natalie Filmann,Goda Kalinauskaite,Inge Tinhofer,Volker Budach,Cihan Gani,Daniel Zips,Tanja Schimek-Jasch,Henning Schäfer,Anca-Ligia Grosu,Emilee A. Thomas,Marie Krause,Hendrik Dapper,Stephanie E. Combs,Caroline Hoffmann,Martin Stuschke,Franziska Walter,Claus Belka,Ina Kurth,Wahyu Wijaya Hadiwikarta,Michael H. Baumann,Claus Rödel,Emmanouil Fokas +24 more
TL;DR: In this article , the authors evaluated prognostic factors based on Cox regression models for disease-free survival (DFS), evaluated variables included age, gender, Karnofsky performance score (KPS), HIV-status, T-category, lymph node status and laboratory parameters.
Book ChapterDOI
Introduction - Biology of Breast Cancer Metastasis and Importance of the Analysis of CTCs.
TL;DR: This introductory chapter will revise the key aspects of Breast cancer metastasis and discuss the importance of CTC analyses in the management of breast cancer patients.
References
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