Contribution of platelets to tumour metastasis.
TLDR
Contributions of platelets to tumour cell survival and spread suggest platelets as a new avenue for therapy.Abstract:
Experimental evidence suggests that platelets contribute to metastasis through adhesive and haemostatic functions that promote cancer cell survival, immune evasion and interactions with vascular cells to assist organ colonization from the bloodstream. Extensive experimental evidence shows that platelets support tumour metastasis. The activation of platelets and the coagulation system have a crucial role in the progression of cancer. Within the circulatory system, platelets guard tumour cells from immune elimination and promote their arrest at the endothelium, supporting the establishment of secondary lesions. These contributions of platelets to tumour cell survival and spread suggest platelets as a new avenue for therapy.read more
Citations
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Microenvironmental regulation of tumor progression and metastasis.
TL;DR: The paradoxical roles of the tumor microenvironment during specific stages of cancer progression and metastasis are discussed, as well as recent therapeutic attempts to re-educate stromal cells within the TME to have anti-tumorigenic effects.
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Emerging Biological Principles of Metastasis
TL;DR: The cellular and molecular mechanisms involved in metastasis are summarized, with a focus on carcinomas where the most is known, and the general principles of metastasis that have begun to emerge are highlighted.
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Direct Signaling between Platelets and Cancer Cells Induces an Epithelial-Mesenchymal-Like Transition and Promotes Metastasis
TL;DR: It is shown that platelet-tumor cell interactions are sufficient to prime tumor cells for subsequent metastasis and inhibit NF-κB signaling in cancer cells, resulting in their transition to an invasive mesenchymal-like phenotype and enhanced metastasis in vivo.
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Pre-metastatic niches: organ-specific homes for metastases
Héctor Peinado,Haiying Zhang,Irina Matei,Bruno Costa-Silva,Ayuko Hoshino,Gonçalo Rodrigues,Gonçalo Rodrigues,Bethan Psaila,Rosandra N. Kaplan,Jacqueline Bromberg,Yibin Kang,Mina J. Bissell,Thomas R. Cox,Amato J. Giaccia,Janine T. Erler,Sachie Hiratsuka,Cyrus M. Ghajar,David Lyden,David Lyden +18 more
TL;DR: This Review summarizes the main processes and new mechanisms involved in the formation of the pre-metastatic niche and describes the main mechanisms used to modify organs of future metastasis.
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The physics of cancer: the role of physical interactions and mechanical forces in metastasis
TL;DR: The metastatic process is reconstructed and the importance of key physical and mechanical processes at each step of the cascade is described, which may help to solve some long-standing questions in disease progression and lead to new approaches to developing cancer diagnostics and therapies.
References
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Increased metastatic potential of tumor cells in von Willebrand factor-deficient mice.
Virginie Terraube,Ronan Pendu,Dominique Baruch,Martijn F.B.G. Gebbink,Dominique Meyer,Peter J. Lenting,Cécile V. Denis +6 more
TL;DR: In vitro adhesion assays revealed that VWF is able to promote a dose‐dependent adhesion of B16‐BL6 cells via its Arg‐Gly‐Asp (RGD) sequence, and suggest thatVWF plays a protective role against tumor cell dissemination in vivo.
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Platelet-derived microparticles and coagulation activation in breast cancer patients
Bettina Toth,Susanne Liebhardt,Kerstin Steinig,Nina Ditsch,Andreas Rank,Ingo Bauerfeind,Michael Spannagl,Klaus Friese,Armin J. Reininger +8 more
TL;DR: It is speculated that platelet-derived microparticles (PMP) act in the microenvironment of tumor tissue and may thus not be an exclusive parameter reflecting in-vivo procoagulant activity.
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Tissue factor activity is increased in a combined platelet and microparticle sample from cancer patients
TL;DR: This study indicates that measurement of TF activity in a combined platelet and microparticle sample can be used as a simple assay to determine the level of circulating TF.
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Platelets: Guardians of Tumor Vasculature
TL;DR: Targeting platelet secretory activities may represent a new approach to specifically destabilize tumor vasculature.
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The platelet count in carcinoma of the lung and colon.
TL;DR: It is postulate that the host response to malignancy, possibly in the form of production of bone marrow-stimulating cytokines, may play a prominent role in regulation of platelet counts in these neoplasms, and that a particularly prominent and persistent degree of marrow stimulation exists in patients with N-SCLC.