Contribution of platelets to tumour metastasis.
TLDR
Contributions of platelets to tumour cell survival and spread suggest platelets as a new avenue for therapy.Abstract:
Experimental evidence suggests that platelets contribute to metastasis through adhesive and haemostatic functions that promote cancer cell survival, immune evasion and interactions with vascular cells to assist organ colonization from the bloodstream. Extensive experimental evidence shows that platelets support tumour metastasis. The activation of platelets and the coagulation system have a crucial role in the progression of cancer. Within the circulatory system, platelets guard tumour cells from immune elimination and promote their arrest at the endothelium, supporting the establishment of secondary lesions. These contributions of platelets to tumour cell survival and spread suggest platelets as a new avenue for therapy.read more
Citations
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Fluid shear stress induces cancer stem cell-like phenotype in MCF7 breast cancer cell line without inducing epithelial to mesenchymal transition.
TL;DR: The results with MCF7 suggest that CTCs can be modeled in vitro as non-adherent cancer cells in FSS and that they show an increased CSC-like signature during circulation, providing new insights to the importance ofCSC-targeting strategies when treating metastatic patients.
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Aspirin, platelet inhibition and cancer prevention
Paola Patrignani,Carlo Patrono +1 more
TL;DR: The clinical pharmacology of low-dose aspirin is examined as a basis for discussing the mechanisms underlying the contribution of platelets to neoplastic transformation and progression of cancer via the development of metastases.
Journal ArticleDOI
Aspirin and P2Y12 inhibition attenuate platelet-induced ovarian cancer cell invasion.
Niamh M. Cooke,Niamh M. Cooke,Cathy D. Spillane,Cathy D. Spillane,Orla Sheils,Orla Sheils,John J. O'Leary,John J. O'Leary,Dermot Kenny,Dermot Kenny +9 more
TL;DR: While there is increasing evidence for the cancer-protective effect of aspirin, this study suggests P2Y12 inhibition may also play a role.
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The pro‐metastatic role of bone marrow‐derived cells: a focus on MSCs and regulatory T cells
Bong Ihn Koh,Yibin Kang +1 more
TL;DR: The role of mesenchymal stem cells and regulatory T cells in cancer metastasis is reviewed to better understand the bipolar nature of these bone marrow‐derived cells in physiological and malignant contexts to pave the way for new therapeutics against metastatic disease.
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Platelets Alter Tumor Cell Attributes to Propel Metastasis: Programming in Transit
TL;DR: It is demonstrated that an epithelial-mesenchymal-like transition can be induced by interaction between platelets and tumor cells.
References
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Journal ArticleDOI
Tumor Angiogenesis: Therapeutic Implications
TL;DR: This new capillary growth is even more vigorous and continuous than a similar outgrowth of capillary sprouts observed in 2016 and is likely to be accompanied by neovascularization.
Journal ArticleDOI
Cancer Metastasis: Building a Framework
Gaorav P. Gupta,Joan Massagué +1 more
TL;DR: Understanding of the origins and nature of cancer metastasis and the selection of traits that are advantageous to cancer cells is promoted.
Journal ArticleDOI
Dissemination and growth of cancer cells in metastatic sites
TL;DR: Inhibition of the growth of metastases in secondary sites offers a promising approach for cancer therapy and could help to improve the treatment of metastatic disease.
Journal ArticleDOI
Microenvironmental regulation of metastasis
TL;DR: Experimental data demonstrating the role of the microenvironment in metastasis is described, areas for future research are identified and possible new therapeutic avenues are suggested.
Journal ArticleDOI
Integrins in cancer: biological implications and therapeutic opportunities
TL;DR: Clinical developments emphasize the need to identify how integrin antagonists influence the tumour and its microenvironment.