Contribution of platelets to tumour metastasis.
TLDR
Contributions of platelets to tumour cell survival and spread suggest platelets as a new avenue for therapy.Abstract:
Experimental evidence suggests that platelets contribute to metastasis through adhesive and haemostatic functions that promote cancer cell survival, immune evasion and interactions with vascular cells to assist organ colonization from the bloodstream. Extensive experimental evidence shows that platelets support tumour metastasis. The activation of platelets and the coagulation system have a crucial role in the progression of cancer. Within the circulatory system, platelets guard tumour cells from immune elimination and promote their arrest at the endothelium, supporting the establishment of secondary lesions. These contributions of platelets to tumour cell survival and spread suggest platelets as a new avenue for therapy.read more
Citations
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Epidermal Growth Factor (EGF) Autocrine Activation of Human Platelets Promotes EGF Receptor-Dependent Oral Squamous Cell Carcinoma Invasion, Migration, and Epithelial Mesenchymal Transition.
TL;DR: HMW-EGF in platelet function is established and a previously unsuspected connection between activated platelets and tumorigenesis is elucidated through rapid, and prolonged, autocrine-stimulated release of HMW- EGF by tumor-associated platelets.
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Namdev Dhas,Mónica C. García,Ritu R. Kudarha,Abhijeet Pandey,Ajinkya Nitin Nikam,Divya Gopalan,Gasper Fernandes,Soji Soman,Sanjay Tammaji Kulkarni,Raviraja N. Seetharam,Ruchi Tiwari,Sarika Wairkar,Chandrakantsing V. Pardeshi,Srinivas Mutalik +13 more
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Enhanced anti-tumor and anti-metastasis therapy for triple negative breast cancer by CD44 receptor-targeted hybrid self-delivery micelles.
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A microfluidic platform with permeable walls for the analysis of vascular and extravascular mass transport
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Understanding the cell survival mechanism of anoikis-resistant cancer cells during different steps of metastasis
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References
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