Curcumin and Type 2 Diabetes Mellitus: Prevention and Treatment
TLDR
Pre-clinical and clinical trials on curcumin supplementation in T2DM are focused on and the peculiar mechanisms by whichCurcumin might ameliorate diabetes management are discussed.Abstract:
Type 2 diabetes mellitus (T2DM) is an ensemble of metabolic diseases that has reached pandemic dimensions all over the world. The multifactorial nature of the pathology makes patient management, which includes lifelong drug therapy and lifestyle modification, extremely challenging. It is well known that T2DM is a preventable disease, therefore lowering the incidence of new T2DM cases could be a key strategy to reduce the global impact of diabetes. Currently, there is growing evidence on the efficacy of the use of medicinal plants supplements for T2DM prevention and management. Among these medicinal plants, curcumin is gaining a growing interest in the scientific community. Curcumin is a bioactive molecule present in the rhizome of the Curcuma longa plant, also known as turmeric. Curcumin has different pharmacological and biological effects that have been described by both in vitro and in vivo studies, and include antioxidant, cardio-protective, anti-inflammatory, anti-microbial, nephro-protective, anti-neoplastic, hepato-protective, immunomodulatory, hypoglycaemic and anti-rheumatic effects. In animal models, curcumin extract delays diabetes development, improves β-cell functions, prevents β-cell death, and decreases insulin resistance. The present review focuses on pre-clinical and clinical trials on curcumin supplementation in T2DM and discusses the peculiar mechanisms by which curcumin might ameliorate diabetes management.read more
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Dietary polyphenols as antidiabetic agents: Advances and opportunities
Chongde Sun,Chao Zhao,Chao Zhao,Esra Çapanoğlu Güven,Paolo De Paoli,Jesus Simal-Gandara,Kunka Mohanram Ramkumar,Shengpeng Wang,Florina Buleu,Ana Maria Pah,Vladiana Turi,Georgiana Damian,Simona Dragan,Merve Tomas,Washim Khan,Mingfu Wang,Dominique Delmas,Dominique Delmas,María P. Portillo,María P. Portillo,Parsa Dar,Lei Chen,Jianbo Xiao +22 more
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Potential therapeutic effects of curcumin mediated by JAK/STAT signaling pathway: A review.
Milad Ashrafizadeh,Hossein Rafiei,Reza Mohammadinejad,Elham Ghasemipour Afshar,Tahereh Farkhondeh,Saeed Samarghandian +5 more
TL;DR: Curcumin is able to enhance the level of anti-inflammatory cytokines and improve inflammatory disorders such as colitis by targeting STAT signaling pathway, and studies show that inhibition of JAK/STAT pathway by curcuming is involved in reduced migration and invasion of cancer cells.
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Pharmaceutical Drugs and Natural Therapeutic Products for the Treatment of Type 2 Diabetes Mellitus.
Jana Blahova,Monika Martiniakova,Martina Babikova,Veronika Kovacova,Vladimira Mondockova,Radoslav Omelka +5 more
TL;DR: In this paper, both pharmaceutical drugs and selected natural products, as well as combination therapies are characterized and the mechanisms of their action and possible negative side effects are also provided, and the combination therapy of synthetic agents and natural compounds with synergistic interactions makes the treatment more efficient.
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Pharmacological properties and underlying mechanisms of curcumin and prospects in medicinal potential.
TL;DR: In this article, the authors highlighted the recent evidence of curcuminoids applied in sevral aspects of medical problem particular in COVID-19 pandemics, and provided deeper insight and understandings of Curcumin's medicinal value in the discovery and development of new drugs.
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Oxidative Stress: Pathogenetic Role in Diabetes Mellitus and Its Complications and Therapeutic Approaches to Correction
TL;DR: In this paper, the authors present modern views about the role of oxidative stress reactions in the pathogenesis of types 1 and 2 diabetes mellitus and their complications based on the analysis of experimental and clinical studies.
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Waller,Linhong Wang,David A Watkins,David A Watkins,Scott Weichenthal,Elisabete Weiderpass,Robert G. Weintraub,Robert G. Weintraub,Andrea Werdecker,Ronny Westerman,Richard A. White,Hywel C Williams,Charles Shey Wiysonge,Charles Shey Wiysonge,Charles D.A. Wolfe,Charles D.A. Wolfe,Sungho Won,Rachel Woodbrook,Mamo Wubshet,Denis Xavier,Gelin Xu,Ajit Kumar Yadav,Lijing L Yan,Yuichiro Yano,Mehdi Yaseri,Mehdi Yaseri,Pengpeng Ye,Henock Yebyo,Henock Yebyo,Paul S. F. Yip,Naohiro Yonemoto,Seok Jun Yoon,Mustafa Z. Younis,Chuanhua Yu,Zoubida Zaidi,Maysaa El Sayed Zaki,Hajo Zeeb,Maigeng Zhou,Maigeng Zhou,Sanjay Zodpey,Liesl Zühlke,Christopher J L Murray +699 more
TL;DR: The Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015) as discussed by the authors was used to estimate the incidence, prevalence, and years lived with disability for diseases and injuries at the global, regional, and national scale over the period of 1990 to 2015.
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