Journal ArticleDOI
Destructive extraction of phospholipids from Escherichia coli membranes by graphene nanosheets
Yusong Tu,Min Lv,Peng Xiu,Tien Huynh,Meng Zhang,Matteo Castelli,Z. Y. Liu,Qing(黄庆) Huang,Chunhai(樊春海) Fan,Haiping(方海平) Fang,Ruhong Zhou,Ruhong Zhou,Ruhong Zhou +12 more
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TLDR
Graphene nanosheets can penetrate into and extract large amounts of phospholipids from the cell membranes because of the strong dispersion interactions between graphene and lipid molecules as mentioned in this paper.Abstract:
Understanding how nanomaterials interact with cell membranes is related to how they cause cytotoxicity and is therefore critical for designing safer biomedical applications. Recently, graphene (a two-dimensional nanomaterial) was shown to have antibacterial activity on Escherichia coli, but its underlying molecular mechanisms remain unknown. Here we show experimentally and theoretically that pristine graphene and graphene oxide nanosheets can induce the degradation of the inner and outer cell membranes of Escherichia coli, and reduce their viability. Transmission electron microscopy shows three rough stages, and molecular dynamics simulations reveal the atomic details of the process. Graphene nanosheets can penetrate into and extract large amounts of phospholipids from the cell membranes because of the strong dispersion interactions between graphene and lipid molecules. This destructive extraction offers a novel mechanism for the molecular basis of graphene's cytotoxicity and antibacterial activity.read more
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Amino-modified graphene oxide nanoplatelets for photo-thermal and anti-bacterial capability
TL;DR: Combination of physical capturing/splintering and photo-thermal effects for the bacteria, it is suggested that amino-functionalized GO nanoplatelets would be anticipated to apply in the anti-bacterial coating and photo themal therapy.
Journal ArticleDOI
Cationic polyesters with antibacterial properties: Facile and controllable synthesis and antibacterial study
Jia Yan,Liuchun Zheng,Kun Hu,Luhai Li,Chuncheng Li,Li Zhu,Hengliang Wang,Yaonan Xiao,Shaohua Wu,Jiajian Liu,Bo Zhang,Fan Zhang +11 more
TL;DR: In this paper, a simple two-step process was used to synthesize biodegradable antimicrobial cationic copolyesters, and the structures of BPBS and QPBS were systematically characterized by NMR, ATR-FTIR, GPC and XPS.
Journal ArticleDOI
Impact of Edge Groups on the Hydration and Aggregation Properties of Graphene Oxide
TL;DR: It was observed that the edge groups contribute up to 51% of the total hydration-free energy and that the PMF indicates the tendency for spontaneous aggregation at all investigated concentrations, being lower the higher the concentration of oxygen.
Journal ArticleDOI
Partner-facilitating transmembrane penetration of nanoparticles: a biological test in silico.
TL;DR: It is interesting to find that the introduction of a partner NP would greatly facilitate the transmembrane penetration of a host spherical NP, and such a partner-facilitating effect in NP translocation also works for a shaped NP although less pronounced.
Journal ArticleDOI
Particle Size-Dependent Antibacterial Activity and Murine Cell Cytotoxicity Induced by Graphene Oxide Nanomaterials
Lin Zhao,Guangxin Duan,Zaixing Yang,Jeffrey K. Weber,Xu Liu,Shunyi Lu,Xuan-Yu Meng,Jiaying Xu +7 more
TL;DR: The size dependence elucidated here provides a useful schematic for tuning GO-cell interactions in biomedical applications and suggests that both the lateral size and surface area of GO particles contribute to cytotoxic effects.
References
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TL;DR: This review analyzes recent trends in graphene research and applications, and attempts to identify future directions in which the field is likely to develop.
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Andre E. Nel,Lutz Mädler,Darrell Velegol,Tian Xia,Eric M.V. Hoek,Ponisseril Somasundaran,Fred Klaessig,Vince Castranova,Mike Thompson +8 more
TL;DR: Probing the various interfaces of nanoparticle/biological interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings.
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