Journal ArticleDOI
Destructive extraction of phospholipids from Escherichia coli membranes by graphene nanosheets
Yusong Tu,Min Lv,Peng Xiu,Tien Huynh,Meng Zhang,Matteo Castelli,Z. Y. Liu,Qing(黄庆) Huang,Chunhai(樊春海) Fan,Haiping(方海平) Fang,Ruhong Zhou,Ruhong Zhou,Ruhong Zhou +12 more
Reads0
Chats0
TLDR
Graphene nanosheets can penetrate into and extract large amounts of phospholipids from the cell membranes because of the strong dispersion interactions between graphene and lipid molecules as mentioned in this paper.Abstract:
Understanding how nanomaterials interact with cell membranes is related to how they cause cytotoxicity and is therefore critical for designing safer biomedical applications. Recently, graphene (a two-dimensional nanomaterial) was shown to have antibacterial activity on Escherichia coli, but its underlying molecular mechanisms remain unknown. Here we show experimentally and theoretically that pristine graphene and graphene oxide nanosheets can induce the degradation of the inner and outer cell membranes of Escherichia coli, and reduce their viability. Transmission electron microscopy shows three rough stages, and molecular dynamics simulations reveal the atomic details of the process. Graphene nanosheets can penetrate into and extract large amounts of phospholipids from the cell membranes because of the strong dispersion interactions between graphene and lipid molecules. This destructive extraction offers a novel mechanism for the molecular basis of graphene's cytotoxicity and antibacterial activity.read more
Citations
More filters
Journal ArticleDOI
Graphene-Based Antimicrobial Biomedical Surfaces
TL;DR: Overall, this review aims to highlight on the potential of these materials, current understanding and knowledge gap in the antimicrobial behavior and biocompatibility to be utilized of their coatings to prevent the cross infections.
Journal ArticleDOI
Vacuolization in Cytoplasm and Cell Membrane Permeability Enhancement Triggered by Micrometer-Sized Graphene Oxide
TL;DR: It is illustrated that even within a short exposure time the mGO sheets can induce the formation of vacuoles in the cytosolic compartment and enhance the cell permeability.
Journal ArticleDOI
Computational Investigations of the Interaction between the Cell Membrane and Nanoparticles Coated with a Pulmonary Surfactant.
TL;DR: This paper investigates how the physicochemical properties of the coating pulmonary surfactant lipids and proteins affect the membrane response for inhaled NPs and pinpoint several key factors in the endocytosis of lipid NPs, including the deformation of the lipstick, coating lipid density, and ligand-receptor binding strength.
Journal ArticleDOI
Multiwall Carbon Nanotubes Induce More Pronounced Transcriptomic Responses in Pseudomonas aeruginosa PG201 than Graphene, Exfoliated Boron Nitride, or Carbon Black
TL;DR: In this paper, the authors analyzed the transcriptomic response to carbonaceous or boron nitride (BN) nanomaterials and showed that, at non-growth-inhibitory, equal mass concentrations (10 mg/L), multiwall carbon nanotubes (MWCNTs) induced differential regulation of 111 genes in Pseudomonas aeruginosa, while graphene, BN, and carbon black caused differential regulation for 44, 26, and 25 genes, respectively.
Journal ArticleDOI
Toxicity of Carbon Nanomaterials and Their Potential Application as Drug Delivery Systems: In Vitro Studies in Caco-2 and MCF-7 Cell Lines.
Rosa Garriga,Tania Herrero-Continente,Miguel Palos,Vicente L. Cebolla,Jesús Osada,Edgar Muñoz,María Jesús Rodríguez-Yoldi +6 more
TL;DR: In vitro toxicity of various carbon nanomaterials in human epithelial colorectal adenocarcinoma (Caco-2) cells and human breast adeno-7 cells is investigated and the potential of these materials as nanocarriers in the field of drug delivery of doxorubicin and camptothecin anticancer drugs was compared.
References
More filters
Journal ArticleDOI
Graphene: Status and Prospects
TL;DR: This review analyzes recent trends in graphene research and applications, and attempts to identify future directions in which the field is likely to develop.
Journal ArticleDOI
Toxic Potential of Materials at the Nanolevel
TL;DR: The establishment of principles and test procedures to ensure safe manufacture and use of nanomaterials in the marketplace is urgently required and achievable.
Journal ArticleDOI
Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics
Xavier Michalet,Fabien Pinaud,Laurent A. Bentolila,James M. Tsay,Sören Doose,J. Jack Li,Gobalakrishnan Sundaresan,Anna M. Wu,Sanjiv S. Gambhir,Sanjiv S. Gambhir,Shimon Weiss +10 more
TL;DR: The new generations of qdots have far-reaching potential for the study of intracellular processes at the single-molecule level, high-resolution cellular imaging, long-term in vivo observation of cell trafficking, tumor targeting, and diagnostics.
Journal ArticleDOI
Understanding biophysicochemical interactions at the nano–bio interface
Andre E. Nel,Lutz Mädler,Darrell Velegol,Tian Xia,Eric M.V. Hoek,Ponisseril Somasundaran,Fred Klaessig,Vince Castranova,Mike Thompson +8 more
TL;DR: Probing the various interfaces of nanoparticle/biological interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings.
Related Papers (5)
Toxicity of Graphene and Graphene Oxide Nanowalls Against Bacteria
Omid Akhavan,Elham Ghaderi +1 more