Journal ArticleDOI
Destructive extraction of phospholipids from Escherichia coli membranes by graphene nanosheets
Yusong Tu,Min Lv,Peng Xiu,Tien Huynh,Meng Zhang,Matteo Castelli,Z. Y. Liu,Qing(黄庆) Huang,Chunhai(樊春海) Fan,Haiping(方海平) Fang,Ruhong Zhou,Ruhong Zhou,Ruhong Zhou +12 more
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TLDR
Graphene nanosheets can penetrate into and extract large amounts of phospholipids from the cell membranes because of the strong dispersion interactions between graphene and lipid molecules as mentioned in this paper.Abstract:
Understanding how nanomaterials interact with cell membranes is related to how they cause cytotoxicity and is therefore critical for designing safer biomedical applications. Recently, graphene (a two-dimensional nanomaterial) was shown to have antibacterial activity on Escherichia coli, but its underlying molecular mechanisms remain unknown. Here we show experimentally and theoretically that pristine graphene and graphene oxide nanosheets can induce the degradation of the inner and outer cell membranes of Escherichia coli, and reduce their viability. Transmission electron microscopy shows three rough stages, and molecular dynamics simulations reveal the atomic details of the process. Graphene nanosheets can penetrate into and extract large amounts of phospholipids from the cell membranes because of the strong dispersion interactions between graphene and lipid molecules. This destructive extraction offers a novel mechanism for the molecular basis of graphene's cytotoxicity and antibacterial activity.read more
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Antibacterial activity of large-area monolayer graphene film manipulated by charge transfer
TL;DR: The results show that the graphene films on Cu and Ge can surprisingly inhibit the growth of both bacteria, especially the former, and a plausible mechanism is proposed here to explain this phenomenon.
Journal ArticleDOI
Assessment of the toxic potential of graphene family nanomaterials
Xiaoqing Guo,Nan Mei +1 more
TL;DR: This review summarizes recent findings on the toxicological effects and the potential toxicity mechanisms of graphene-family nanomaterials in bacteria, mammalian cells, and animal models.
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Functional graphene nanosheets: The next generation membranes for water desalination
TL;DR: In this article, the authors highlight the structure and preparation of NPG and GO membranes and discuss the recent experiments, computer simulations and theoretical models, addressing the unique mechanical properties, ion selectivity, and possible transport mechanisms through NPG/GO membranes.
Journal ArticleDOI
2D nanostructures for water purification: graphene and beyond
TL;DR: Progress in the development of nanoporous graphene and graphene oxide (GO) membranes, the mechanism of graphene molecular sieve action, structural design, hydrophilic nature, mechanical strength and antifouling properties and the principal challenges associated with nanopore generation are discussed in detail.
Journal ArticleDOI
Activation of biologically relevant levels of reactive oxygen species by Au/g-C3N4 hybrid nanozyme for bacteria killing and wound disinfection.
TL;DR: The integration of AuNPs with ultrathin graphitic carbon nitride (g-C3N4) provides excellent peroxidase-activity, which can catalyze the decomposition of H2O2 to OH radicals much more efficiently, allowing the use of bio-safety levels of H 2O2 for the first time.
References
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TL;DR: This review analyzes recent trends in graphene research and applications, and attempts to identify future directions in which the field is likely to develop.
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Toxic Potential of Materials at the Nanolevel
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Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics
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Andre E. Nel,Lutz Mädler,Darrell Velegol,Tian Xia,Eric M.V. Hoek,Ponisseril Somasundaran,Fred Klaessig,Vince Castranova,Mike Thompson +8 more
TL;DR: Probing the various interfaces of nanoparticle/biological interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings.
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