Journal ArticleDOI
Destructive extraction of phospholipids from Escherichia coli membranes by graphene nanosheets
Yusong Tu,Min Lv,Peng Xiu,Tien Huynh,Meng Zhang,Matteo Castelli,Z. Y. Liu,Qing(黄庆) Huang,Chunhai(樊春海) Fan,Haiping(方海平) Fang,Ruhong Zhou,Ruhong Zhou,Ruhong Zhou +12 more
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TLDR
Graphene nanosheets can penetrate into and extract large amounts of phospholipids from the cell membranes because of the strong dispersion interactions between graphene and lipid molecules as mentioned in this paper.Abstract:
Understanding how nanomaterials interact with cell membranes is related to how they cause cytotoxicity and is therefore critical for designing safer biomedical applications. Recently, graphene (a two-dimensional nanomaterial) was shown to have antibacterial activity on Escherichia coli, but its underlying molecular mechanisms remain unknown. Here we show experimentally and theoretically that pristine graphene and graphene oxide nanosheets can induce the degradation of the inner and outer cell membranes of Escherichia coli, and reduce their viability. Transmission electron microscopy shows three rough stages, and molecular dynamics simulations reveal the atomic details of the process. Graphene nanosheets can penetrate into and extract large amounts of phospholipids from the cell membranes because of the strong dispersion interactions between graphene and lipid molecules. This destructive extraction offers a novel mechanism for the molecular basis of graphene's cytotoxicity and antibacterial activity.read more
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Journal ArticleDOI
Theragnostic application of nanoparticle and CRISPR against food-borne multi-drug resistant pathogens
Rahul Bhattacharjee,Aditya Nandi,Priyam Mitra,K. Saha,Paritosh Patel,Ealisha Jha,Pritam Kumar Panda,Sushil Kumar Singh,A. Dutt,Yogendra Kumar Mishra,Suresh K. Verma,Mrutyunjay Suar +11 more
TL;DR: In this paper , the authors have discussed the diagnostic application of CRISPR-Cas technologies along with their potential usage in applications like phage resistance, phage vaccination, strain typing, genome editing, and antimicrobial.
Journal ArticleDOI
A Nanoporous Graphene/Nitrocellulose Membrane Beneficial to Wound Healing
Shaobo Du,Shaobo Du,Bin Liu,Zhan Li,Hongxin Tan,Wei Qi,Tianqi Liu,Shirong Qiang,Taofeng Zhang,Fuxiang Song,Xiujuan Chen,Jia Chen,Hongdeng Qiu,Hongdeng Qiu,Wangsuo Wu +14 more
TL;DR: After using the nanoporous graphene/nitrocellulose membrane, the wound closure percentage reaches 93.03 ± 1.08% at 7 days after the trauma, and the degree of skin tissue recovery is also improved significantly, which develops a highly efficient wound healing dressing, which is expected to be used directly in clinics.
Journal ArticleDOI
Cellular Injection Using Carbon Nanotube: A Molecular Dynamics Study
TL;DR: It is shown that the tilt angle of the CNT influences the nanotube's buckling and may result in destroying the membrane structure during the injection process, and CNT's chirality distinctly affects the results.
Journal ArticleDOI
Self-Assembled Micellar Structures of Lipopeptides With Variable Number of Attached Lipid Chains Revealed by Atomistic Molecular Dynamics Simulations
TL;DR: Atomic molecular dynamics simulation study of the self-assembly behavior of toll-like agonist lipopeptides (Pam nCSK4) in aqueous solutions may provide potential insights into their bioactivities and contribute to the design of bioactive medicines or drug carriers.
Book ChapterDOI
Antimicrobial activity of graphene-based nanomaterials: Current development and challenges
Kaizar Hossain,Kaizar Hossain,Mohd Rafatullah,Syed Zaghum Abbas,Akil Ahmad,Norli Ismail,Avasn Y. Maruthi +6 more
TL;DR: This chapter outlines the progress of development of the antimicrobial efficacy of graphene and graphene-based nanocomposite materials, and gives a new understanding or insight for the development of nanoantibacterial or antimicrobial studies.
References
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TL;DR: This review analyzes recent trends in graphene research and applications, and attempts to identify future directions in which the field is likely to develop.
Journal ArticleDOI
Toxic Potential of Materials at the Nanolevel
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Understanding biophysicochemical interactions at the nano–bio interface
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TL;DR: Probing the various interfaces of nanoparticle/biological interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings.
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