Journal ArticleDOI
Destructive extraction of phospholipids from Escherichia coli membranes by graphene nanosheets
Yusong Tu,Min Lv,Peng Xiu,Tien Huynh,Meng Zhang,Matteo Castelli,Z. Y. Liu,Qing(黄庆) Huang,Chunhai(樊春海) Fan,Haiping(方海平) Fang,Ruhong Zhou,Ruhong Zhou,Ruhong Zhou +12 more
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TLDR
Graphene nanosheets can penetrate into and extract large amounts of phospholipids from the cell membranes because of the strong dispersion interactions between graphene and lipid molecules as mentioned in this paper.Abstract:
Understanding how nanomaterials interact with cell membranes is related to how they cause cytotoxicity and is therefore critical for designing safer biomedical applications. Recently, graphene (a two-dimensional nanomaterial) was shown to have antibacterial activity on Escherichia coli, but its underlying molecular mechanisms remain unknown. Here we show experimentally and theoretically that pristine graphene and graphene oxide nanosheets can induce the degradation of the inner and outer cell membranes of Escherichia coli, and reduce their viability. Transmission electron microscopy shows three rough stages, and molecular dynamics simulations reveal the atomic details of the process. Graphene nanosheets can penetrate into and extract large amounts of phospholipids from the cell membranes because of the strong dispersion interactions between graphene and lipid molecules. This destructive extraction offers a novel mechanism for the molecular basis of graphene's cytotoxicity and antibacterial activity.read more
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Functionalized graphene oxide in microbial engineering: An effective stimulator for bacterial growth
TL;DR: NGO-PEG (1:1) treatment could remarkably enhance (up to 6-fold) recombinant protein production in engineered bacteria cells, the first demonstration of functionalized GO as a novel, positive regulator in microbial engineering, and highlights the critical role of surface chemistry in modulating the interactions between nanomaterials and microorganisms.
Journal ArticleDOI
Interfacing Graphene-Based Materials With Neural Cells
Mattia Bramini,Giulio Alberini,Giulio Alberini,Elisabetta Colombo,Martina Chiacchiaretta,Martina Chiacchiaretta,Mattia L. DiFrancesco,José Fernando Maya-Vetencourt,Luca Maragliano,Fabio Benfenati,Fabio Benfenati,Fabrizia Cesca +11 more
TL;DR: The state-of-the-art in the use of graphene materials to engineer three-dimensional scaffolds to drive neuronal growth and regeneration in vivo, and the possibility of using graphene as a component of hybrid composites/multi-layer organic electronics devices are described.
Journal ArticleDOI
Lentinan-Functionalized Graphene Oxide Is an Effective Antigen Delivery System That Modulates Innate Immunity and Improves Adaptive Immunity
Zhenguang Liu,Jin He,Tianyu Zhu,Cong Hu,Ruonan Bo,Adelijiang Wusiman,Yuanliang Hu,Deyun Wang +7 more
TL;DR: It is demonstrated that GO-LNT could suffice for a safe and effective vaccine delivery system as well as an excellent adjuvant that both elicits a long-term immune memory response and potentiates cellular and humoral immunity.
Journal ArticleDOI
Simulation of nanoparticles interacting with a cell membrane: probing the structural basis and potential biomedical application
Xiao Zhang,Guanghui Ma,Wei Wei +2 more
TL;DR: Wei et al. as discussed by the authors reviewed the current advances in nano-bio interfaces from the perspective of simulations, and determined how the properties of nanoparticles affect their interactions with cell membranes to provide insights for the design of NPs and summarize their corresponding biomedical applications.
Journal ArticleDOI
Silver Covalently Bound to Cyanographene Overcomes Bacterial Resistance to Silver Nanoparticles and Antibiotics
David Panáček,Lucie Hochvaldová,Aristides Bakandritsos,Tomáš Malina,Michal Langer,Jan Belza,Jana Martincová,Renata Večeřová,Petr Lazar,Kateřina Poláková,Jan Kolařík,Lucie Válková,Milan Kolář,Michal Otyepka,Aleš Panáček,Radek Zbořil +15 more
TL;DR: GCN/Ag shows that rigid supports selectively and densely functionalized with potent silver‐binding ligands, such as cyanographene, may open new avenues against microbial resistance.
References
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TL;DR: This review analyzes recent trends in graphene research and applications, and attempts to identify future directions in which the field is likely to develop.
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Understanding biophysicochemical interactions at the nano–bio interface
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TL;DR: Probing the various interfaces of nanoparticle/biological interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings.
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