Journal ArticleDOI
Destructive extraction of phospholipids from Escherichia coli membranes by graphene nanosheets
Yusong Tu,Min Lv,Peng Xiu,Tien Huynh,Meng Zhang,Matteo Castelli,Z. Y. Liu,Qing(黄庆) Huang,Chunhai(樊春海) Fan,Haiping(方海平) Fang,Ruhong Zhou,Ruhong Zhou,Ruhong Zhou +12 more
Reads0
Chats0
TLDR
Graphene nanosheets can penetrate into and extract large amounts of phospholipids from the cell membranes because of the strong dispersion interactions between graphene and lipid molecules as mentioned in this paper.Abstract:
Understanding how nanomaterials interact with cell membranes is related to how they cause cytotoxicity and is therefore critical for designing safer biomedical applications. Recently, graphene (a two-dimensional nanomaterial) was shown to have antibacterial activity on Escherichia coli, but its underlying molecular mechanisms remain unknown. Here we show experimentally and theoretically that pristine graphene and graphene oxide nanosheets can induce the degradation of the inner and outer cell membranes of Escherichia coli, and reduce their viability. Transmission electron microscopy shows three rough stages, and molecular dynamics simulations reveal the atomic details of the process. Graphene nanosheets can penetrate into and extract large amounts of phospholipids from the cell membranes because of the strong dispersion interactions between graphene and lipid molecules. This destructive extraction offers a novel mechanism for the molecular basis of graphene's cytotoxicity and antibacterial activity.read more
Citations
More filters
Journal ArticleDOI
Graphdiyne–hemin-mediated catalytic system for wound disinfection and accelerated wound healing
Arbab Ali,Arbab Ali,Jiaming Liu,Huige Zhou,Tao Liu,Muhammad Ovais,Huibiao Liu,Yukui Rui,Chunying Chen +8 more
TL;DR: GDY-Hemin has good biocompatibility and is suitable for wound infection treatment in vivo, and can decompose hydrogen peroxide to generate highly-toxic hydroxyl radicals that impair bacterial cell membrane and ultimately leading to bacteria death.
Journal ArticleDOI
Adsorption and binding dynamics of graphene-supported phospholipid membranes using the QCM-D technique.
Daniel Melendrez,Thomas A. Jowitt,Maria Iliut,Andrea Francesco Verre,Stefan Goodwin,Aravind Vijayaraghavan +5 more
TL;DR: The journal’s standard Terms & Conditions and the ethical guidelines, outlined in the author and reviewer resource centre, still apply.
Journal ArticleDOI
Biomimetic graphene for enhanced interaction with the external membrane of astrocytes
Margherita Durso,Ana I. Borrachero-Conejo,Cristian Bettini,Emanuele Treossi,Alessandra Scidà,Emanuela Saracino,Massimo Gazzano,Meganne Christian,Vittorio Morandi,Giulia Tuci,Giuliano Giambastiani,Luca Ottaviano,Francesco Perrozzi,Valentina Benfenati,Manuela Melucci,Vincenzo Palermo +15 more
TL;DR: The results indicate that the reported biomimetic approach could be applied to neural prosthesis to improve cell colonization and avoid glial scar formation in brain implants and improved adhesion could be extremely relevant in devices targeting neural cell sensing/modulation of physiological activity.
Journal ArticleDOI
Functionalized ultrathin palladium nanosheets as patches for HepG2 cancer cells
TL;DR: The results show through surface functionalization Pd nanosheets can be modified to interact differently with HepG2 cancerous cells, resulting in varied cytotoxicity.
Journal ArticleDOI
Detecting Interactions between Nanomaterials and Cell Membranes by Synthetic Nanopores.
TL;DR: A nanopore-based single-molecule approach is demonstrated that can be applied to monitor a specific nanomaterial-membrane interaction in real time and it is shown how an ionic current can be used to detect membrane damage by a graphene nanosheet.
References
More filters
Journal ArticleDOI
Graphene: Status and Prospects
TL;DR: This review analyzes recent trends in graphene research and applications, and attempts to identify future directions in which the field is likely to develop.
Journal ArticleDOI
Toxic Potential of Materials at the Nanolevel
TL;DR: The establishment of principles and test procedures to ensure safe manufacture and use of nanomaterials in the marketplace is urgently required and achievable.
Journal ArticleDOI
Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics
Xavier Michalet,Fabien Pinaud,Laurent A. Bentolila,James M. Tsay,Sören Doose,J. Jack Li,Gobalakrishnan Sundaresan,Anna M. Wu,Sanjiv S. Gambhir,Sanjiv S. Gambhir,Shimon Weiss +10 more
TL;DR: The new generations of qdots have far-reaching potential for the study of intracellular processes at the single-molecule level, high-resolution cellular imaging, long-term in vivo observation of cell trafficking, tumor targeting, and diagnostics.
Journal ArticleDOI
Understanding biophysicochemical interactions at the nano–bio interface
Andre E. Nel,Lutz Mädler,Darrell Velegol,Tian Xia,Eric M.V. Hoek,Ponisseril Somasundaran,Fred Klaessig,Vince Castranova,Mike Thompson +8 more
TL;DR: Probing the various interfaces of nanoparticle/biological interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings.
Related Papers (5)
Toxicity of Graphene and Graphene Oxide Nanowalls Against Bacteria
Omid Akhavan,Elham Ghaderi +1 more