Journal ArticleDOI
Destructive extraction of phospholipids from Escherichia coli membranes by graphene nanosheets
Yusong Tu,Min Lv,Peng Xiu,Tien Huynh,Meng Zhang,Matteo Castelli,Z. Y. Liu,Qing(黄庆) Huang,Chunhai(樊春海) Fan,Haiping(方海平) Fang,Ruhong Zhou,Ruhong Zhou,Ruhong Zhou +12 more
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TLDR
Graphene nanosheets can penetrate into and extract large amounts of phospholipids from the cell membranes because of the strong dispersion interactions between graphene and lipid molecules as mentioned in this paper.Abstract:
Understanding how nanomaterials interact with cell membranes is related to how they cause cytotoxicity and is therefore critical for designing safer biomedical applications. Recently, graphene (a two-dimensional nanomaterial) was shown to have antibacterial activity on Escherichia coli, but its underlying molecular mechanisms remain unknown. Here we show experimentally and theoretically that pristine graphene and graphene oxide nanosheets can induce the degradation of the inner and outer cell membranes of Escherichia coli, and reduce their viability. Transmission electron microscopy shows three rough stages, and molecular dynamics simulations reveal the atomic details of the process. Graphene nanosheets can penetrate into and extract large amounts of phospholipids from the cell membranes because of the strong dispersion interactions between graphene and lipid molecules. This destructive extraction offers a novel mechanism for the molecular basis of graphene's cytotoxicity and antibacterial activity.read more
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Journal ArticleDOI
Membrane destruction and phospholipid extraction by using two-dimensional MoS2 nanosheets
TL;DR: This newly discovered mechanism of molybdenum disulfide (MoS2) nanosheets to disrupt the cell membrane may promote the application of transition metal dichalcogenide (TMD) nanomaterials in designing remarkable antibacterial materials in the near future.
Journal ArticleDOI
Revealing the Nature of Interaction between Graphene Oxide and Lipid Membrane by Surface-Enhanced Infrared Absorption Spectroscopy.
Lie Wu,Li Zeng,Xiue Jiang +2 more
TL;DR: Analysis of GO-induced vibrational changes of interfacial water and lipid membrane with surface-enhanced infrared absorption (SEIRA) spectroscopy provides evidence that overcoming the electrostatic repulsion of phosphate group, its hydrogen bonding attraction as well as the electro static and hydrophobic interaction of choline group are the driving forces for the effective adsorption of GO on lipid membrane.
Journal ArticleDOI
Graphene-based functional nanomaterials for biomedical and bioanalysis applications
Twinkle Mathew,R. Aishwarya Sree,S. Aishwarya,Khan Kounaina,Anirudh Gururaj Patil,Pankaj Satapathy,Shivaprasad Hudeda,Sunil S. More,K. Muthucheliyan,T.R. Naveen Kumar,Anjanapura V. Raghu,Kakarla Raghava Reddy,Farhan Zameer +12 more
TL;DR: In this paper, a review of the recent advances in the synthesis and encapsulation of graphene-based nanomaterials is presented, where the major therapeutic application of graphene in various diseases like cancer, neuro-regeneration, anti-viral (Ebola and Zika) are described.
Journal ArticleDOI
Modulating Aβ33–42 Peptide Assembly by Graphene Oxide
Qiang Li,Lei Liu,Lei Liu,Shuai Zhang,Meng Xu,Xueqin Wang,Chen Wang,Flemming Besenbacher,Mingdong Dong +8 more
TL;DR: Atomic force microscopy temporal evolution measurements reveal that the initial binding between the peptide monomer and the large available surface of the GO sheets can redirect the assembly pathway of amyloid beta.
Journal ArticleDOI
Recent advances in mitigating membrane biofouling using carbon-based materials
Yichao Wu,Yinfeng Xia,Xinxin Jing,Peng Cai,Avanthi Deshani Igalavithana,Chuyang Y. Tang,Daniel C.W. Tsang,Yong Sik Ok +7 more
TL;DR: A comprehensive review of the recent progress in the application of CBMs in antibiofouling membrane, especially carbon nanotubes and graphene family materials, is provided.
References
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Journal ArticleDOI
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TL;DR: This review analyzes recent trends in graphene research and applications, and attempts to identify future directions in which the field is likely to develop.
Journal ArticleDOI
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Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics
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Understanding biophysicochemical interactions at the nano–bio interface
Andre E. Nel,Lutz Mädler,Darrell Velegol,Tian Xia,Eric M.V. Hoek,Ponisseril Somasundaran,Fred Klaessig,Vince Castranova,Mike Thompson +8 more
TL;DR: Probing the various interfaces of nanoparticle/biological interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings.
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