Journal ArticleDOI
Destructive extraction of phospholipids from Escherichia coli membranes by graphene nanosheets
Yusong Tu,Min Lv,Peng Xiu,Tien Huynh,Meng Zhang,Matteo Castelli,Z. Y. Liu,Qing(黄庆) Huang,Chunhai(樊春海) Fan,Haiping(方海平) Fang,Ruhong Zhou,Ruhong Zhou,Ruhong Zhou +12 more
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TLDR
Graphene nanosheets can penetrate into and extract large amounts of phospholipids from the cell membranes because of the strong dispersion interactions between graphene and lipid molecules as mentioned in this paper.Abstract:
Understanding how nanomaterials interact with cell membranes is related to how they cause cytotoxicity and is therefore critical for designing safer biomedical applications. Recently, graphene (a two-dimensional nanomaterial) was shown to have antibacterial activity on Escherichia coli, but its underlying molecular mechanisms remain unknown. Here we show experimentally and theoretically that pristine graphene and graphene oxide nanosheets can induce the degradation of the inner and outer cell membranes of Escherichia coli, and reduce their viability. Transmission electron microscopy shows three rough stages, and molecular dynamics simulations reveal the atomic details of the process. Graphene nanosheets can penetrate into and extract large amounts of phospholipids from the cell membranes because of the strong dispersion interactions between graphene and lipid molecules. This destructive extraction offers a novel mechanism for the molecular basis of graphene's cytotoxicity and antibacterial activity.read more
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Journal ArticleDOI
Repulsive interactions of a lipid membrane with graphene in composite materials
TL;DR: In this paper, the van der Waals interaction between a lipid membrane and a substrate covered by a graphene sheet is investigated using the Lifshitz theory and the reflection coefficients are obtained for a layered planar system submerged in water.
Journal ArticleDOI
Encapsulation of Graphene in the Hydrophobic Core of a Lipid Bilayer.
Hadi Arjmandi-Tash,Lia M. C. Lima,Liubov A. Belyaeva,Tetiana Mukhina,Giovanna Fragneto,Alexander Kros,Thierry Charitat,Grégory F. Schneider +7 more
TL;DR: Theoretical simulations have predicted that a lipid bilayer forms a stable superstructure when a sheet of graphene is inserted in its hydrophobic core, and this work experimentally produced for the first time a lipid–graphene–lipid assembly by combining the Langmuir–Blodgett and the LangMuir–Schaefer methods.
Book ChapterDOI
Molecular Simulations of Complex Membrane Models
D. Jefferies,S. Khalid +1 more
TL;DR: In this chapter, several simulation studies of complex membranes are discussed.
Journal ArticleDOI
Tuning cell behavior with nanoparticle shape.
Edoardo Scarpa,Cesare De Pace,Adrian Joseph,Senio Campos De Souza,Alessandro Poma,Eva Liatsi-Douvitsa,Claudia Contini,Claudia Contini,Valeria De Matteis,Josep Martí,Giuseppe Battaglia,Loris Rizzello,Loris Rizzello +12 more
TL;DR: It is demonstrated that combining the intrinsic shape-dependent effects of tubes with the delivery of doxorubicin significantly increases the cytotoxicity of the system.
References
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Andre E. Nel,Lutz Mädler,Darrell Velegol,Tian Xia,Eric M.V. Hoek,Ponisseril Somasundaran,Fred Klaessig,Vince Castranova,Mike Thompson +8 more
TL;DR: Probing the various interfaces of nanoparticle/biological interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings.
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