Journal ArticleDOI
Destructive extraction of phospholipids from Escherichia coli membranes by graphene nanosheets
Yusong Tu,Min Lv,Peng Xiu,Tien Huynh,Meng Zhang,Matteo Castelli,Z. Y. Liu,Qing(黄庆) Huang,Chunhai(樊春海) Fan,Haiping(方海平) Fang,Ruhong Zhou,Ruhong Zhou,Ruhong Zhou +12 more
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TLDR
Graphene nanosheets can penetrate into and extract large amounts of phospholipids from the cell membranes because of the strong dispersion interactions between graphene and lipid molecules as mentioned in this paper.Abstract:
Understanding how nanomaterials interact with cell membranes is related to how they cause cytotoxicity and is therefore critical for designing safer biomedical applications. Recently, graphene (a two-dimensional nanomaterial) was shown to have antibacterial activity on Escherichia coli, but its underlying molecular mechanisms remain unknown. Here we show experimentally and theoretically that pristine graphene and graphene oxide nanosheets can induce the degradation of the inner and outer cell membranes of Escherichia coli, and reduce their viability. Transmission electron microscopy shows three rough stages, and molecular dynamics simulations reveal the atomic details of the process. Graphene nanosheets can penetrate into and extract large amounts of phospholipids from the cell membranes because of the strong dispersion interactions between graphene and lipid molecules. This destructive extraction offers a novel mechanism for the molecular basis of graphene's cytotoxicity and antibacterial activity.read more
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Graphene oxide based coatings on nitinol for biomedical implant applications: effectively promote mammalian cell growth but kill bacteria
Changhong Zhao,Changhong Zhao,Santosh Pandit,Yifeng Fu,Ivan Mijakovic,Aldo Jesorka,Johan Liu,Johan Liu +7 more
TL;DR: GO-based coatings on NiTi combine the antimicrobial activity and improved biocompatibility and therefore present a remarkable potential in biomedical implant applications.
Journal ArticleDOI
Preclinical assessment on neuronal regeneration in the injury-related microenvironment of graphene-based scaffolds.
Yun Qian,Xu Wang,Jialin Song,Wei Chen,Shuai Chen,Yi Jin,Yuanming Ouyang,Weien Yuan,Cunyi Fan +8 more
TL;DR: Wang et al. as discussed by the authors investigated the potential toxicity of layered graphene-loaded polycaprolactone scaffold after implantation during 18 months in vivo and further identified possible biologically regenerative effects of this scaffold on myelination, axonal outgrowth, and locomotor function recovery.
Journal ArticleDOI
Low levels of graphene and graphene oxide inhibit cellular xenobiotic defense system mediated by efflux transporters
Su Liu,Wei Jiang,Wu Bing,Jing Yu,Haiyan Yu,Xu-Xiang Zhang,Cristina Torres-Duarte,Gary N. Cherr +7 more
TL;DR: Graphene and GO are not environmentally safe since they can significantly make cell more susceptible to other xenobiotics, and this chemosensitizing activity should be considered in the risk assessment of graphene and GO.
Journal ArticleDOI
Antipathogenic properties and applications of low-dimensional materials.
Z L Shaw,Sruthi Kuriakose,Samuel Cheeseman,Michael D. Dickey,Jan Genzer,Andrew J. Christofferson,Russell J. Crawford,Christopher F McConville,James Chapman,Vi Khanh Truong,Vi Khanh Truong,Aaron Elbourne,Sumeet Walia +12 more
TL;DR: In this article, a critical assessment of current low-dimensional materials (LDMs) and their mechanism of action for antimicrobial applications is provided. And future design considerations and constraints in deploying LDM-based applications are discussed.
Journal ArticleDOI
Antibacterial ability and hemocompatibility of graphene functionalized germanium
TL;DR: To improve the biocompatibility of Ge-based device, graphene film is directly deposited on the Ge surface with different coverage area by controlling the growth time to provide some new insights into the relationship between antibacterial ability and hemocomp compatibility based on graphene functionalized biomedical device.
References
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