Journal ArticleDOI
Destructive extraction of phospholipids from Escherichia coli membranes by graphene nanosheets
Yusong Tu,Min Lv,Peng Xiu,Tien Huynh,Meng Zhang,Matteo Castelli,Z. Y. Liu,Qing(黄庆) Huang,Chunhai(樊春海) Fan,Haiping(方海平) Fang,Ruhong Zhou,Ruhong Zhou,Ruhong Zhou +12 more
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TLDR
Graphene nanosheets can penetrate into and extract large amounts of phospholipids from the cell membranes because of the strong dispersion interactions between graphene and lipid molecules as mentioned in this paper.Abstract:
Understanding how nanomaterials interact with cell membranes is related to how they cause cytotoxicity and is therefore critical for designing safer biomedical applications. Recently, graphene (a two-dimensional nanomaterial) was shown to have antibacterial activity on Escherichia coli, but its underlying molecular mechanisms remain unknown. Here we show experimentally and theoretically that pristine graphene and graphene oxide nanosheets can induce the degradation of the inner and outer cell membranes of Escherichia coli, and reduce their viability. Transmission electron microscopy shows three rough stages, and molecular dynamics simulations reveal the atomic details of the process. Graphene nanosheets can penetrate into and extract large amounts of phospholipids from the cell membranes because of the strong dispersion interactions between graphene and lipid molecules. This destructive extraction offers a novel mechanism for the molecular basis of graphene's cytotoxicity and antibacterial activity.read more
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Journal ArticleDOI
Bacterial Adhesion to Graphene Oxide (GO)-Functionalized Interfaces Is Determined by Hydrophobicity and GO Sheet Spatial Orientation
Jinkai Xue,Sara BinAhmed,Zhaoxing Wang,Nathan G. Karp,Benjamin L. Stottrup,Santiago Romero-Vargas Castrillón +5 more
TL;DR: In this paper, the authors investigate the adhesion of single Pseudomonas fluorescens cells on GO-functionalized interfaces possessing distinct morphologies and observe strong adhesion forces on both Si-GO and PLL-GO surfaces.
Journal ArticleDOI
Liposome/Graphene Oxide Interaction Studied by Isothermal Titration Calorimetry.
TL;DR: This study suggests the release of more water molecules from the GO surface when mixed with DOTAPliposomes, which can be rationalized by the full rupture of the DOTAP liposome interacting with the whole GO surface, including hydrophobic regions, while DOPC liposomes only interact with a small area on GO near the edge, which is likely to be more hydrophilic.
Journal ArticleDOI
A Macromolecular Drug for Cancer Therapy via Extracellular Calcification
Ning Tang,Hanhui Li,Lihong Zhang,Xueyun Zhang,Yanni Chen,Hao Shou,Shuaishuai Feng,Xinhua Chen,Yan Luo,Ruikang Tang,Ben Wang +10 more
TL;DR: In this article, a macromolecular-induced extracellular chemotherapy involving biomineralization by absorbing calcium from the blood through a new type of drug, polysialic acid conjugated with folate (folate-polySia), which selectively induces biogenic mineral formation on tumor cells and results in pathological calcification of tumors.
Journal ArticleDOI
Morphology Change and Detachment of Lipid Bilayers from the Mica Substrate Driven by Graphene Oxide Sheets
TL;DR: It was found that the bare lipid bilayer dramatically expanded in height and would be unstable and detachable from the mica substrates as induced by GO, and the detached lipid molecules were found to bind to the GO surface.
Journal ArticleDOI
Intranasal vaccination with influenza HA/GO-PEI nanoparticles provides immune protection against homo- and heterologous strains.
Chunhong Dong,Ye Wang,Gilbert X. Gonzalez,Yao Ma,Yufeng Song,Shelly Wang,Sang-Moo Kang,Richard W. Compans,Bao-Zhong Wang +8 more
TL;DR: In this article, polyethyleneimine-functionalized graphene oxide nanoparticles (GP nanoparticles) showed high antigen-loading capacities and superior immunoenhancing properties, and incorporated influenza hemagglutinin (HA) was incorporated into GP nanoparticles and maintained structural integrity and antigenicity.
References
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Understanding biophysicochemical interactions at the nano–bio interface
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TL;DR: Probing the various interfaces of nanoparticle/biological interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings.
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