Journal ArticleDOI
Destructive extraction of phospholipids from Escherichia coli membranes by graphene nanosheets
Yusong Tu,Min Lv,Peng Xiu,Tien Huynh,Meng Zhang,Matteo Castelli,Z. Y. Liu,Qing(黄庆) Huang,Chunhai(樊春海) Fan,Haiping(方海平) Fang,Ruhong Zhou,Ruhong Zhou,Ruhong Zhou +12 more
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TLDR
Graphene nanosheets can penetrate into and extract large amounts of phospholipids from the cell membranes because of the strong dispersion interactions between graphene and lipid molecules as mentioned in this paper.Abstract:
Understanding how nanomaterials interact with cell membranes is related to how they cause cytotoxicity and is therefore critical for designing safer biomedical applications. Recently, graphene (a two-dimensional nanomaterial) was shown to have antibacterial activity on Escherichia coli, but its underlying molecular mechanisms remain unknown. Here we show experimentally and theoretically that pristine graphene and graphene oxide nanosheets can induce the degradation of the inner and outer cell membranes of Escherichia coli, and reduce their viability. Transmission electron microscopy shows three rough stages, and molecular dynamics simulations reveal the atomic details of the process. Graphene nanosheets can penetrate into and extract large amounts of phospholipids from the cell membranes because of the strong dispersion interactions between graphene and lipid molecules. This destructive extraction offers a novel mechanism for the molecular basis of graphene's cytotoxicity and antibacterial activity.read more
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Nanophysical Antimicrobial Strategies: A Rational Deployment of Nanomaterials and Physical Stimulations in Combating Bacterial Infections
Bingqing Jia,Xuancheng Du,Weijie Wang,Yu Chao Qu,Xiangdong Liu,Ming-Zhong Zhao,Weifeng Li,Yong-Qiang Li +7 more
TL;DR: NPAS are categorized according to the modes of their physical stimulation, which include mechanical, optical, magnetic, acoustic, and electrical signals, with a focus on their design and antimicrobial mechanisms.
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Achieving stem cell imaging and osteogenic differentiation by using nitrogen doped graphene quantum dots
TL;DR: Nitrogen doped graphene quantum dots have the abilities to promote rBMSCs osteogenic differentiation and pave the way for application of N-GQDs in regenerative medicine fields.
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Dual Inhibitory Pathways of Metallofullerenol Gd@C 82 (OH) 22 on Matrix Metalloproteinase-2: Molecular insight into drug-like nanomedicine
Seung-gu Kang,Raul Araya-Secchi,Deqiang Wang,Bo Wang,Tien Huynh,Ruhong Zhou,Ruhong Zhou,Ruhong Zhou +7 more
TL;DR: These findings not only illustrated how the inhibitory mechanism of Gd@C82(OH)22 is distinguished between the two gelatinase MMPs with atomic details, but also shed light on the de novo design of anti-metastatic nanotherapeutics with enhanced target specificity.
Journal ArticleDOI
Design of Small Nanoparticles Decorated with Amphiphilic Ligands: Self-Preservation Effect and Translocation into a Plasma Membrane.
Yuchi Liu,Shixin Li,Xuejuan Liu,Hainan Sun,Tongtao Yue,Xianren Zhang,Bing Yan,Bing Yan,Dapeng Cao +8 more
TL;DR: This work takes into account the cascading effect of NP functionalization on interactions with target cell membranes by determining coatings of biomolecules in biological media and proposes an amphiphilic ligand coating on NPs.
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Graphene- and Nanoparticle-Embedded Antimicrobial and Biocompatible Cotton/Silk Fabrics for Protective Clothing
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References
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