Journal ArticleDOI
Destructive extraction of phospholipids from Escherichia coli membranes by graphene nanosheets
Yusong Tu,Min Lv,Peng Xiu,Tien Huynh,Meng Zhang,Matteo Castelli,Z. Y. Liu,Qing(黄庆) Huang,Chunhai(樊春海) Fan,Haiping(方海平) Fang,Ruhong Zhou,Ruhong Zhou,Ruhong Zhou +12 more
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TLDR
Graphene nanosheets can penetrate into and extract large amounts of phospholipids from the cell membranes because of the strong dispersion interactions between graphene and lipid molecules as mentioned in this paper.Abstract:
Understanding how nanomaterials interact with cell membranes is related to how they cause cytotoxicity and is therefore critical for designing safer biomedical applications. Recently, graphene (a two-dimensional nanomaterial) was shown to have antibacterial activity on Escherichia coli, but its underlying molecular mechanisms remain unknown. Here we show experimentally and theoretically that pristine graphene and graphene oxide nanosheets can induce the degradation of the inner and outer cell membranes of Escherichia coli, and reduce their viability. Transmission electron microscopy shows three rough stages, and molecular dynamics simulations reveal the atomic details of the process. Graphene nanosheets can penetrate into and extract large amounts of phospholipids from the cell membranes because of the strong dispersion interactions between graphene and lipid molecules. This destructive extraction offers a novel mechanism for the molecular basis of graphene's cytotoxicity and antibacterial activity.read more
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Surface modification of titanium implants with micro–nano-topography and NIR photothermal property for treating bacterial infection and promoting osseointegration
TL;DR: In this article, a double acid corrosion and subsequent hydrothermal treatment were used to fabricate a micro-nano-structured Ti substrates (Ti-M-N).
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Molecular insights into the uptake of SiO2 nanoparticles on phospholipid membrane: Effect of surface properties and particle size
TL;DR: In this paper , molecular dynamics simulations were employed to study the uptake process of SiO2 NPs into DPPC bilayers. And the authors reported a complete description of the interaction between SiO 2 NPs and DPPC Bilayer, aiming to provide some insights for the further work on the bioaccumulation and hemolytic activity of siO2NPs.
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Antibacterial amorphous magnesium phosphate/graphene oxide for accelerating bone regeneration.
TL;DR: In this paper , a novel in situ synthesized AMP powders containing 0.05, 0.25, and 1 wt% of graphene oxide (AMP/GO) were developed to achieve a favorable degradation rate, desirable antibacterial properties against both Escherichia coli ( E. coli ), Staphylococcus aureus ( S. aureUS ), and S.
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Multifunctional graphene oxide for bioimaging: Emphasis on biological research
TL;DR: Graphene oxide (GO) nanomaterials offer a wide range of bioimaging applicability and is a good theranostic tool, while enabling tracing in vivo pharmacokinetics during concurrent treatment.
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Hyaluronic Acid-Based Nanomaterials as a New Approach to the Treatment and Prevention of Bacterial Infections
TL;DR: Recent works on numerous types of HA-based nanoparticles are discussed to overcome the limitations of traditional antibiotics in the treatment of bacterial infections and allow the complete eradication of pathogenic microorganisms.
References
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TL;DR: This review analyzes recent trends in graphene research and applications, and attempts to identify future directions in which the field is likely to develop.
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Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics
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Understanding biophysicochemical interactions at the nano–bio interface
Andre E. Nel,Lutz Mädler,Darrell Velegol,Tian Xia,Eric M.V. Hoek,Ponisseril Somasundaran,Fred Klaessig,Vince Castranova,Mike Thompson +8 more
TL;DR: Probing the various interfaces of nanoparticle/biological interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings.
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