Journal ArticleDOI
Destructive extraction of phospholipids from Escherichia coli membranes by graphene nanosheets
Yusong Tu,Min Lv,Peng Xiu,Tien Huynh,Meng Zhang,Matteo Castelli,Z. Y. Liu,Qing(黄庆) Huang,Chunhai(樊春海) Fan,Haiping(方海平) Fang,Ruhong Zhou,Ruhong Zhou,Ruhong Zhou +12 more
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TLDR
Graphene nanosheets can penetrate into and extract large amounts of phospholipids from the cell membranes because of the strong dispersion interactions between graphene and lipid molecules as mentioned in this paper.Abstract:
Understanding how nanomaterials interact with cell membranes is related to how they cause cytotoxicity and is therefore critical for designing safer biomedical applications. Recently, graphene (a two-dimensional nanomaterial) was shown to have antibacterial activity on Escherichia coli, but its underlying molecular mechanisms remain unknown. Here we show experimentally and theoretically that pristine graphene and graphene oxide nanosheets can induce the degradation of the inner and outer cell membranes of Escherichia coli, and reduce their viability. Transmission electron microscopy shows three rough stages, and molecular dynamics simulations reveal the atomic details of the process. Graphene nanosheets can penetrate into and extract large amounts of phospholipids from the cell membranes because of the strong dispersion interactions between graphene and lipid molecules. This destructive extraction offers a novel mechanism for the molecular basis of graphene's cytotoxicity and antibacterial activity.read more
Citations
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Bovine serum albumin bioconjugated graphene oxide: Red blood cell adhesion and hemolysis studied by QCM-D
TL;DR: Improved the hemocompatibility especial hemolysis properties of GO nanosheets by grafting bovine serum albumin (BSA).
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Environmental transformation of graphene oxide in the aquatic environment
TL;DR: This review will arouse the realization of potential risk that GO can bring to the aquatic environment and enlighten us to pay attention to behaviors of other two-dimensional GO-like nanomaterials, which have been intensively applied and studied in recent years.
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Remarkable Antibacterial Activity of Reduced Graphene Oxide Functionalized by Copper Ions
Yusong Tu,Yusong Tu,Pei Li,Jiajia Sun,Jie Jiang,Fangfang Dai,Chengzhang Li,Yuanyan Wu,Liang Chen,Guosheng Shi,Yanwen Tan,Haiping Fang,Haiping Fang +12 more
TL;DR: It is experimentally shown that the functionality of reduced graphene oxide through copper ions displays selective antibacterial activity that is significantly stronger than that of rGO itself and no toxicity to mammalian cells.
Journal ArticleDOI
Toxicity of Two-Dimensional Layered Materials and Their Heterostructures.
Eveline Sheau Tan,Bang Lin Li,Bang Lin Li,Katsuhiko Ariga,Katsuhiko Ariga,Chwee Teck Lim,Slaven Garaj,David Tai Leong +7 more
TL;DR: This review focusses on the biological and toxicity effects of 2D LMs; their associated mechanisms linking their chemistries to their biological endpoints and aims to help researchers to predict and mitigate any toxic effects.
Journal ArticleDOI
Polymethyl Methacrylate-Based Bone Cements Containing Carbon Nanotubes and Graphene Oxide: An Overview of Physical, Mechanical, and Biological Properties.
Sanaz Soleymani Eil Bakhtiari,Hamid Reza Bakhsheshi-Rad,Saeed Karbasi,Mohamadreza Tavakoli,Mahmood Razzaghi,Ahmad Fauzi Ismail,Seeram Ramakrishna,Filippo Berto +7 more
TL;DR: This review article aims to evaluate mechanical properties, self-setting characteristics, biocompatibility, and bioactivity of the PMMA-based BCs composites containing carbon nanotubes (CNTs), graphene oxide (GO), and carbon-based compounds.
References
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