Journal ArticleDOI
Determination of the helix and beta form of proteins in aqueous solution by circular dichroism.
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This article is published in Biochemistry.The article was published on 1974-07-30. It has received 1986 citations till now. The article focuses on the topics: Circular dichroism & Helix.read more
Citations
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Noncovalent triblock copolymers based on a coiled-coil peptide motif.
Hana Robson Marsden,Alexander V. Korobko,Ellen N. M. van Leeuwen,Emilie Pouget,Sandra J. Veen,Nico A. J. M. Sommerdijk,Alexander Kros +6 more
TL;DR: The self-assembly of the polymer-peptide conjugates is compared to that of polystyrene-b-poly(ethylene glycol), emphasizing the importance of the coiled-coil peptide block in determining micellar structure and dynamic behavior.
Journal ArticleDOI
Stabilization of proteins by rational design of α-helix stability using helix/coil transition theory
TL;DR: It is demonstrated that by using a helix/coil algorithm to design helix-stabilizing mutations on the solvent-exposed face of helices, it is possible to rationally increase the stability of proteins.
Journal ArticleDOI
Computational design of highly selective antimicrobial peptides.
TL;DR: It is found that the cosine of the angle between two sequence moments obtained with different hydrophobicity scales, defined as the D-descriptor, identifies highly selective peptide antibiotics.
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Inhibition of Human Immunodeficiency Virus Type 1 Infectivity by the gp41 Core: Role of a Conserved Hydrophobic Cavity in Membrane Fusion
TL;DR: Results indicate that the conserved hydrophobic coiled-coil cavity in the gp41 core is critical for HIV-1 entry and its inhibition and provides a potential antiviral drug target.
Journal ArticleDOI
The amphiphilic alpha-helix concept. Consequences on the structure of staphylococcal delta-toxin in solution and bound to lipids.
Eric Thiaudière,Odile Siffert,Jean-Claude Talbot,Jacques Bolard,Joseph E. Alouf,Jean Dufourcq +5 more
TL;DR: It is proposed that delta-toxin probably lies parallel to the surface, only penetrating weakly in lipids, depending on their packing, and a structural model of aggregated species is proposed with stacked antiparallel amphipathic rods.
References
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Journal ArticleDOI
Computed circular dichroism spectra for the evaluation of protein conformation
Journal ArticleDOI
Determination of the secondary structures of proteins by circular dichroism and optical rotatory dispersion.
Journal ArticleDOI
Structure of hen egg-white lysozyme. A three-dimensional Fourier synthesis at 2 Angstrom resolution.
C. C. F. Blake,D. F. Koenig,D. F. Koenig,G. A. Mair,A. C. T. North,D. C. Phillips,V. R. Sarma +6 more
TL;DR: Structure of Hen Egg-White Lysozyme: A Three-dimensional Fourier Synthesis at 2 A Resolution as mentioned in this paper, 3D Fourier synthesis at 2 a resolution.
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Structure of Myoglobin: A Three-Dimensional Fourier Synthesis at 2 Å. Resolution
J. C. Kendrew,R. E. Dickerson,B. E. Strandberg,R G Hart,D R Davies,D. C. Phillips,V. C. Shore +6 more