Journal ArticleDOI
Determination of the helix and beta form of proteins in aqueous solution by circular dichroism.
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This article is published in Biochemistry.The article was published on 1974-07-30. It has received 1986 citations till now. The article focuses on the topics: Circular dichroism & Helix.read more
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Structurally Minimized μ-Conotoxin Analogues as Sodium Channel Blockers: Implications for Designing Conopeptide-Based Therapeutics
Tiffany S. Han,Min Min Zhang,Aleksandra Walewska,Aleksandra Walewska,Pawel Gruszczynski,Pawel Gruszczynski,Pawel Gruszczynski,Charles R. Robertson,Thomas E. Cheatham,Doju Yoshikami,Baldomero M. Olivera,Grzegorz Bulaj +11 more
TL;DR: The successful efforts in minimizing the size of μ‐conotoxin while retaining its biological activity are described.
Journal ArticleDOI
Characterization of the unfolding process of lipocalin-type prostaglandin D synthase
TL;DR: L-PGDS is a unique protein whose enzyme activity and ligand-binding property are biphasically altered during the unfolding process by denaturant, as monitored by CD spectra of the bound ligands.
Journal ArticleDOI
Polyphenylene dendrimers as scaffolds for shape-persistent multiple peptide conjugates.
Gueorgui Mihov,Dörthe Grebel-Koehler,Anke Lübbert,Guido W. M. Vandermeulen,Andreas Herrmann,Harm-Anton Klok,Klaus Müllen +6 more
TL;DR: Novel functionalized cyclopentadienones have been synthesized whose Diels-Alder cycloaddition with various core molecules leads to polyphenylene dendrimers possessing (protected) amino or carboxyl groups, which allows the design of a dendritic scaffold with a specific number of different anchor groups on its periphery.
Journal ArticleDOI
Circular dichroism and conformational analysis of the membrane‐modifying peptide ‐N‐t‐Boc‐(Aib‐L‐Ala)5‐Gly‐Ala‐Aib‐Pro‐Ala‐Aib‐Aib‐Glu‐(OBzl)‐Gln‐OMe with respect to alamethicin
R. Oekonomopulos,Günther Jung +1 more
TL;DR: The conformational analysis of the CD spectrum is reported for the synthetic and membrane‐modifying nonadecapeptide analog of alamethicin N‐t‐Boc‐(Aib‐L‐Ala)5‐Gly‐AlA‐AIB‐Pro‐Al a‐Aib-Aib'Glu(OBzl)‐ Gln‐OMe.
Journal ArticleDOI
Structure of the membrane reconstituted transmembrane-juxtamembrane peptide EGFR(622-660) and its interaction with Ca2+/calmodulin.
TL;DR: Solid-state NMR and polarized FTIR measurements of peptides corresponding to the TM plus JM regions of EGFR reconstituted in model phospholipid membranes are presented to address the role of the short cytoplasmic JM sequence in regulating EGFR activity and show that the TM domain is helical with a transition to non-helical structure at the TM-JM boundary.
References
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Journal ArticleDOI
Computed circular dichroism spectra for the evaluation of protein conformation
Journal ArticleDOI
Determination of the secondary structures of proteins by circular dichroism and optical rotatory dispersion.
Journal ArticleDOI
Structure of hen egg-white lysozyme. A three-dimensional Fourier synthesis at 2 Angstrom resolution.
C. C. F. Blake,D. F. Koenig,D. F. Koenig,G. A. Mair,A. C. T. North,D. C. Phillips,V. R. Sarma +6 more
TL;DR: Structure of Hen Egg-White Lysozyme: A Three-dimensional Fourier Synthesis at 2 A Resolution as mentioned in this paper, 3D Fourier synthesis at 2 a resolution.
Journal ArticleDOI
Structure of Myoglobin: A Three-Dimensional Fourier Synthesis at 2 Å. Resolution
J. C. Kendrew,R. E. Dickerson,B. E. Strandberg,R G Hart,D R Davies,D. C. Phillips,V. C. Shore +6 more