Journal ArticleDOI
Eine neue Methode zur Synthese von Peptiden: Aktivierung der Carboxylgruppe mit Dicyclohexylcarbodiimid unter Zusatz von 1‐Hydroxy‐benzotriazolen
Wolfgang König,Rolf Geiger +1 more
TLDR
In this article, the authors show that 1-Hydroxy-benzotriazol and 1-hydroxy-acetyl carbodiimid-methode eignen sich als Zusatze bei der Dicyclohexylcarbodiimids-Methode zur Synthese von Peptiden, verhindern die N-Acyl-harnstoffbildung and fuhren in hoher Ausbeute.Abstract:
1-Hydroxy-benzotriazol sowie verschiedene kernsubstituierte 1-Hydroxy-benzotriazole eignen sich als Zusatze bei der Dicyclohexylcarbodiimid-Methode zur Synthese von Peptiden. Ihr Einflus auf die Racemisierung bei Peptidsynthesen wurde unter Anwendung des gaschromatographischen Racemisierungstests von Weygand u. Mitarbb.2) untersucht. Die neuen Zusatze senken die Racemisierung, verhindern die N-Acyl-harnstoffbildung und fuhren in hoher Ausbeute zu sehr reinen Peptiden.read more
Citations
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Enzymatic synthesis of dipeptide units of the D-D-configuration in aqueous media
TL;DR: The enzymatic synthesis of dipeptide units of the D-D-configuration in aqueous media, catalysed by muramoyl-pentapeptide carboxypeptidase (E.C.4.3.8), is described.
Journal ArticleDOI
4-Cyano-α-methyl-l-phenylalanine as a Spectroscopic Marker for the Investigation of PeptaibioticMembrane Interactions
Marta De Zotti,Sara Bobone,Annalisa Bortolotti,Edoardo Longo,Barbara Biondi,Cristina Peggion,Fernando Formaggio,Claudio Toniolo,Andrea Dalla Bona,Bernard Kaptein,Lorenzo Stella +10 more
TL;DR: Results indicate that both labeled analogs essentially maintain the overall helical propensity of the naturally occurring lipopeptaibiotic, and confirm literature results that some of the spectroscopic parameters of the 4‐cyanobenzyl chromophore are sensitive markers of the local microenvironment.
Journal ArticleDOI
Peptide Segment Separation by Tertiary Peptide Bonds. Synthesis and Conformational Analysis of Cross-Linked Polystyrene Resin-Bound Human Proinsulin C-Peptide Fragments
TL;DR: In order to clarify the role of tertiary peptide bonds in the conformational development of protected peptides in organic solvents, cross-linked polystyrene resin-bound human proinsulin C-peptide fragments were prepared by a fragment condensation method.
Journal ArticleDOI
Recyclable DMAP-Functionalized polymeric nanoreactors for highly efficient acylation of alcohols in aqueous systems
Jiaqi Qiu,Fuliang Meng,Maolin Wang,Jinjin Huang,Chengzhan Wang,Xiao Li,Guang Yang,Zan Hua,Tao Chen +8 more
TL;DR: In this paper, small-molecule catalysts 4-(N,N-dimethylamino)pyridine (DMAP) functionalized nanoreactors were constructed by self-assembly of amphiphilic block copolymers with DMAP moieties in the hydrophobic block, leading to heterogeneous catalysts with excellent dispersity in water.
Journal ArticleDOI
An extension of the ‘Bip method’: induced axial chirality in a series of dipeptides based on Bip/β2,2-HBip combined with Ala/β3-HAla
Laurence Dutot,Anne Gaucher,Karen Wright,Michel Wakselman,Jean-Paul Mazaleyrat,Simona Oancea,Cristina Peggion,Fernando Formaggio,Claudio Toniolo +8 more
TL;DR: Results were confirmed by low-temperature 1H NMR spectroscopy studies of the dipeptides in CDCl3 and CD3OD solutions, showing two diastereoisomeric conformers in significantly different populations for Boc-Bip- l -β3-HAla-OMe inCD3OD.
References
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Journal ArticleDOI
The Use of Esters of N-Hydroxysuccinimide in Peptide Synthesis
Journal ArticleDOI
t-Butyl Esters of Amino Acids and Peptides and their Use in Peptide Synthesis1
Journal ArticleDOI
Zur Synthese des Glucagons, X. Darstellung der Sequenz 22–29
Erich Wünsch,Fritz Drees +1 more
TL;DR: In this paper, the geschutzte Teilsequenz 22-29 des Glucagons, wird auf zwei verschiedenen Wegen synthetisiert.