Journal ArticleDOI
Eine neue Methode zur Synthese von Peptiden: Aktivierung der Carboxylgruppe mit Dicyclohexylcarbodiimid unter Zusatz von 1‐Hydroxy‐benzotriazolen
Wolfgang König,Rolf Geiger +1 more
TLDR
In this article, the authors show that 1-Hydroxy-benzotriazol and 1-hydroxy-acetyl carbodiimid-methode eignen sich als Zusatze bei der Dicyclohexylcarbodiimids-Methode zur Synthese von Peptiden, verhindern die N-Acyl-harnstoffbildung and fuhren in hoher Ausbeute.Abstract:
1-Hydroxy-benzotriazol sowie verschiedene kernsubstituierte 1-Hydroxy-benzotriazole eignen sich als Zusatze bei der Dicyclohexylcarbodiimid-Methode zur Synthese von Peptiden. Ihr Einflus auf die Racemisierung bei Peptidsynthesen wurde unter Anwendung des gaschromatographischen Racemisierungstests von Weygand u. Mitarbb.2) untersucht. Die neuen Zusatze senken die Racemisierung, verhindern die N-Acyl-harnstoffbildung und fuhren in hoher Ausbeute zu sehr reinen Peptiden.read more
Citations
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Modulation of the activity and assessment of the receptor selectivity in a series of new RGD-containing peptides.
TL;DR: One of the short linear peptides investigated, in which the piperidine carboxylic group was attached to the N-terminus of KGDW, not only strongly inhibited platelet aggregation, but also selectively abolished cell adhesion mediated by GPIIb-IIIa without effect on the vitronectin receptor.
Journal ArticleDOI
Application of cyclic ketones in MCR: Ugi/amide coupling based synthesis of fused tetrazolo[1,5-a][1,4]benzodiazepines
TL;DR: Azido-Ugi reaction involving cyclic ketone, primary amine, isonitrile, and azide afforded substituted tetrazole derivatives 5. These intermediates were hydrolyzed to corresponding acid derivatives as discussed by the authors.
Journal ArticleDOI
Efficient approach to synthesis of two-chain asymmetric cysteine analogs of receptor-binding region of transforming growth factor-α
James P. Tam,Zhi-Yi Shen +1 more
TL;DR: An approach to the synthesis of two-chain analogs containing an intermolecular disulfide linked A-chain and the 17-residue carboxyl fragment (C-fragment) possessing receptor-binding activity using the Boc-benzyl protecting group strategy is described.
Journal ArticleDOI
Conformational restriction through C alpha i C alpha i cyclization: Ac12c, the largest cycloaliphatic C alpha,alpha- disubstituted glycine known.
Michele Saviano,Rosa Iacovino,Rosa Iacovino,Valeria Menchise,Ettore Benedetti,Ettore Benedetti,Gian Maria Bonora,Maddalena Gatos,Laura Graci,Fernando Formaggio,Marco Crisma,Claudio Toniolo +11 more
TL;DR: The results obtained point to the conclusion that beta-bends and 3(10)-helices are preferentially adopted by peptides based on Ac(12)c, the largest cycloaliphatic C-disubstituted glycine known.
Journal ArticleDOI
Synthesis of ribonucleoside 3′,5′‐cyclic phosphorothioates using a modified hydroxybenzotriazole phosphotriester approach
TL;DR: In this paper, a 3-5-dihydroxyl ribonucleosides with O-(2-chlorophenyl) O, O-bis[6-(trifluoromethyl)-1-benzotriazolyl] phosphorothioate, followed by addition of N-methyl-imidazole and removal of protecting groups, gives ribon nucleosides 3 −5−5−cyclic (3 −5 −cyclic) cyclic (cyclic).
References
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Journal ArticleDOI
The Use of Esters of N-Hydroxysuccinimide in Peptide Synthesis
Journal ArticleDOI
t-Butyl Esters of Amino Acids and Peptides and their Use in Peptide Synthesis1
Journal ArticleDOI
Zur Synthese des Glucagons, X. Darstellung der Sequenz 22–29
Erich Wünsch,Fritz Drees +1 more
TL;DR: In this paper, the geschutzte Teilsequenz 22-29 des Glucagons, wird auf zwei verschiedenen Wegen synthetisiert.