Journal ArticleDOI
Eine neue Methode zur Synthese von Peptiden: Aktivierung der Carboxylgruppe mit Dicyclohexylcarbodiimid unter Zusatz von 1‐Hydroxy‐benzotriazolen
Wolfgang König,Rolf Geiger +1 more
TLDR
In this article, the authors show that 1-Hydroxy-benzotriazol and 1-hydroxy-acetyl carbodiimid-methode eignen sich als Zusatze bei der Dicyclohexylcarbodiimids-Methode zur Synthese von Peptiden, verhindern die N-Acyl-harnstoffbildung and fuhren in hoher Ausbeute.Abstract:
1-Hydroxy-benzotriazol sowie verschiedene kernsubstituierte 1-Hydroxy-benzotriazole eignen sich als Zusatze bei der Dicyclohexylcarbodiimid-Methode zur Synthese von Peptiden. Ihr Einflus auf die Racemisierung bei Peptidsynthesen wurde unter Anwendung des gaschromatographischen Racemisierungstests von Weygand u. Mitarbb.2) untersucht. Die neuen Zusatze senken die Racemisierung, verhindern die N-Acyl-harnstoffbildung und fuhren in hoher Ausbeute zu sehr reinen Peptiden.read more
Citations
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Role of peptide backbone conformation on biological activity of chemotactic peptides.
Andrew R. Dentino,Periathamby Antony Raj,Krishna K. Bhandary,Mark E. Wilson,Michael J. Levine +4 more
TL;DR: The finding that all four peptides have ED50 (the molar concentration of peptide to induce half-maximal enzyme release) values in the 10(-8)-10(-9) M range suggests that an induced fit mechanism may indeed be important in this ligand-receptor interaction.
Journal ArticleDOI
Synthesis and wettability characteristics of model adhesive protein sequences inspired by a marine mussel.
TL;DR: The correlation between wettability and adhesion with the alternative substitution by hydrophobic Ala and hydrophilic Thr in the synthetic RMAPs in aqueous solution and as films on high and low surface free energy (sfe) surfaces has been investigated by surface chemical approaches.
Journal ArticleDOI
Mechanism of membrane activity of the antibiotic trichogin GA IV : A two-state transition controlled by peptide concentration
Claudia Mazzuca,Lorenzo Stella,Mariano Venanzi,Fernando Formaggio,Claudio Toniolo,Basilio Pispisa +5 more
TL;DR: The mechanism of trichogin action can be envisaged as based on a two-state transition controlled by peptide concentration, one state is the monomeric, surface bound and inactive peptide, and the other state is a buried, aggregated form, which is responsible for membrane leakage and bioactivity.
Journal ArticleDOI
Solution Phase Synthesis of Alamethicin I
R. Nagaraj,Padmanabhan Balaram +1 more
TL;DR: In this article, the authors reported the total synthesis of alamethicin I by solution phase methods, which was achieved by coupling Z-Ail+PrhAib-OH and Boc-Ala-AibAiwMe as shown in Fig. 2.
Journal ArticleDOI
Transesterification catalyzed by iron(III) β-diketonate species
TL;DR: In this article, a practical and clean protocol for transesterification catalyzed by a 5-mol% cheap, non-toxic and moisture stable Fe(acac)3 or other iron(III) β-diketonate species in solvent, such as heptane under azeotropic condition is developed.
References
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Journal ArticleDOI
The Use of Esters of N-Hydroxysuccinimide in Peptide Synthesis
Journal ArticleDOI
t-Butyl Esters of Amino Acids and Peptides and their Use in Peptide Synthesis1
Journal ArticleDOI
Zur Synthese des Glucagons, X. Darstellung der Sequenz 22–29
Erich Wünsch,Fritz Drees +1 more
TL;DR: In this paper, the geschutzte Teilsequenz 22-29 des Glucagons, wird auf zwei verschiedenen Wegen synthetisiert.