Journal ArticleDOI
Eine neue Methode zur Synthese von Peptiden: Aktivierung der Carboxylgruppe mit Dicyclohexylcarbodiimid unter Zusatz von 1‐Hydroxy‐benzotriazolen
Wolfgang König,Rolf Geiger +1 more
TLDR
In this article, the authors show that 1-Hydroxy-benzotriazol and 1-hydroxy-acetyl carbodiimid-methode eignen sich als Zusatze bei der Dicyclohexylcarbodiimids-Methode zur Synthese von Peptiden, verhindern die N-Acyl-harnstoffbildung and fuhren in hoher Ausbeute.Abstract:
1-Hydroxy-benzotriazol sowie verschiedene kernsubstituierte 1-Hydroxy-benzotriazole eignen sich als Zusatze bei der Dicyclohexylcarbodiimid-Methode zur Synthese von Peptiden. Ihr Einflus auf die Racemisierung bei Peptidsynthesen wurde unter Anwendung des gaschromatographischen Racemisierungstests von Weygand u. Mitarbb.2) untersucht. Die neuen Zusatze senken die Racemisierung, verhindern die N-Acyl-harnstoffbildung und fuhren in hoher Ausbeute zu sehr reinen Peptiden.read more
Citations
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New fluorogenic substrates for the study of secondary specificity of prolyl oligopeptidase
TL;DR: The secondary specificity of prolyl oligopeptidase (POP) has been studied by using a series of fluorogenic substrates containing the highly fluorescent 7-amino-4-methyl-2-quinolinone (AMeq) marker.
Journal ArticleDOI
The Importance of the Peptide Bond at Position 2 in HCO‐Met‐Leu‐Phe‐OMe Analogues as shown by Studies on Human Neutrophils
TL;DR: The formylpeptides formyl‐methionyl‐Nmethylleucyl‐ phenylaline methyl ester and analogue 2 were synthesized in order to investigate the role of the amide bond at position 2 on biological activities on human neutrophils.
Journal ArticleDOI
A novel bleomycin model compound bearing hydrophilic steric factor exhibited high oxygen activating capacity
TL;DR: In this paper, the bleomycin (BLM) model compound bearing hydrophilic steric factor was synthesized and physicochemical properties of the metal complexes were studied, showing that the metal complex exhibited BLM like reversible redox cycle and higher oxygen activating activity compared to the corresponding model compound.
Journal ArticleDOI
Total Synthesis of Minosaminomycin
TL;DR: A component of the antibiotic minosaminomycin (1) was synthesized from D-inositol by catalytic oxidation of an axial hydroxyl group followed by reduction of the ketoxime as discussed by the authors.
Journal ArticleDOI
Importance of the third amino acid residue of oxytocin for its action on isolated rat uterus: study of relationship between hormone conformation and activity.
TL;DR: A reorientation of the tyrosine sidechain, caused by the presence of a neighboring aromatic sidechain in position 3, away from the surface of the 20-membered ring is though to remove the phenolic hydroxyl group from its optimal position in the "active center" of oxytocin and give rise to the reduced efficacy of oxypressin.
References
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Journal ArticleDOI
The Use of Esters of N-Hydroxysuccinimide in Peptide Synthesis
Journal ArticleDOI
t-Butyl Esters of Amino Acids and Peptides and their Use in Peptide Synthesis1
Journal ArticleDOI
Zur Synthese des Glucagons, X. Darstellung der Sequenz 22–29
Erich Wünsch,Fritz Drees +1 more
TL;DR: In this paper, the geschutzte Teilsequenz 22-29 des Glucagons, wird auf zwei verschiedenen Wegen synthetisiert.