Journal ArticleDOI
Eine neue Methode zur Synthese von Peptiden: Aktivierung der Carboxylgruppe mit Dicyclohexylcarbodiimid unter Zusatz von 1‐Hydroxy‐benzotriazolen
Wolfgang König,Rolf Geiger +1 more
TLDR
In this article, the authors show that 1-Hydroxy-benzotriazol and 1-hydroxy-acetyl carbodiimid-methode eignen sich als Zusatze bei der Dicyclohexylcarbodiimids-Methode zur Synthese von Peptiden, verhindern die N-Acyl-harnstoffbildung and fuhren in hoher Ausbeute.Abstract:
1-Hydroxy-benzotriazol sowie verschiedene kernsubstituierte 1-Hydroxy-benzotriazole eignen sich als Zusatze bei der Dicyclohexylcarbodiimid-Methode zur Synthese von Peptiden. Ihr Einflus auf die Racemisierung bei Peptidsynthesen wurde unter Anwendung des gaschromatographischen Racemisierungstests von Weygand u. Mitarbb.2) untersucht. Die neuen Zusatze senken die Racemisierung, verhindern die N-Acyl-harnstoffbildung und fuhren in hoher Ausbeute zu sehr reinen Peptiden.read more
Citations
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Journal ArticleDOI
INTRAMOLECULAR EXCIPLEX FORMATION IN Nα‐ACETYL‐1‐PYRENYLALANYL‐1‐METHYLTRYPTOPHAN METHYLESTER
TL;DR: In this article, the synthesis, absorption and emission properties of erythro and threo (t) Na-acetyl-1-pyrenylalanyl-1methyltryptophan methylester (APTE) are reported.
Journal ArticleDOI
Amino acid derivatives, part 3: New peptide and glycopeptide derivatives conjugated naphthalene. Synthesis, antitumor, anti‐HIV, and BVDV evaluation
TL;DR: A series of peptide derivatives conjugated naphthalene residue 11–25, the glycoside 27 as well as the 7-glycoside 30, and the 2-(2-hydroxy-3-(N-benzyl-N-isopropylamino)propoxy)naphthalenes bearing methionine 31 were synthesized and evaluated in vitro for cytotoxicity against HIV-1 and bovine viral diarrhea virus (BVDV).
Journal ArticleDOI
The Bakerian Lecture: Towards Synthesis of Proteins
TL;DR: The structure of the big gastrins, isolated by Gregory & Tracy (1972), has been elucidated and the sequence of human big gastrin 1 (figure 1) has been synthesized by a collaborative effort between the laboratory at Liverpool and that of Professor E. Wünsch in the Max Planck Institute at Munich.
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Synthesis of substrate analogues for trypanothione reductase
TL;DR: The synthesis and chemical characterisation of a range of substrate analogues for trypanothione reductase are described, with the spermidine portion of trypanothsione replaced by the 3-dimethylaminopropylamide moiety.
Journal ArticleDOI
Kinetics of the alkaline hydrolysis of several n-benzyloxycarbonyldipeptide methyl and ethyl esters
D.A. Hoogwater,M. Peereboom +1 more
TL;DR: In this paper, the reaction rates of synthesized N-protected dipeptide methyl and ethyl esters were studied systematically from the kinetic data the energies of activation, the preexponential factors and the reference values at 40°C were calculated.
References
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Journal ArticleDOI
The Use of Esters of N-Hydroxysuccinimide in Peptide Synthesis
Journal ArticleDOI
t-Butyl Esters of Amino Acids and Peptides and their Use in Peptide Synthesis1
Journal ArticleDOI
Zur Synthese des Glucagons, X. Darstellung der Sequenz 22–29
Erich Wünsch,Fritz Drees +1 more
TL;DR: In this paper, the geschutzte Teilsequenz 22-29 des Glucagons, wird auf zwei verschiedenen Wegen synthetisiert.