Journal ArticleDOI
Eine neue Methode zur Synthese von Peptiden: Aktivierung der Carboxylgruppe mit Dicyclohexylcarbodiimid unter Zusatz von 1‐Hydroxy‐benzotriazolen
Wolfgang König,Rolf Geiger +1 more
TLDR
In this article, the authors show that 1-Hydroxy-benzotriazol and 1-hydroxy-acetyl carbodiimid-methode eignen sich als Zusatze bei der Dicyclohexylcarbodiimids-Methode zur Synthese von Peptiden, verhindern die N-Acyl-harnstoffbildung and fuhren in hoher Ausbeute.Abstract:
1-Hydroxy-benzotriazol sowie verschiedene kernsubstituierte 1-Hydroxy-benzotriazole eignen sich als Zusatze bei der Dicyclohexylcarbodiimid-Methode zur Synthese von Peptiden. Ihr Einflus auf die Racemisierung bei Peptidsynthesen wurde unter Anwendung des gaschromatographischen Racemisierungstests von Weygand u. Mitarbb.2) untersucht. Die neuen Zusatze senken die Racemisierung, verhindern die N-Acyl-harnstoffbildung und fuhren in hoher Ausbeute zu sehr reinen Peptiden.read more
Citations
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Role of the phenylalanine B25 side chain in directing insulin interaction with its receptor. Steric and conformational effects.
S H Nakagawa,H S Tager +1 more
TL;DR: The results showed that the rate of dissociation of receptor-bound 125I-labeled insulin from isolated hepatocytes is enhanced by incubating cells with insulin or [naphthyl(2)-alanineB25]insulin, but not with analogs in which PheB25 is replaced by serine, leucine, or homophenylalanine; deletion of residues B26-B30, however, results in analogs that enhance the rate.
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A Fully Synthetic Vaccine Consisting of a Tumor‐Associated Glycopeptide Antigen and a T‐Cell Epitope for the Induction of a Highly Specific Humoral Immune Response
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Ester coupling reactions – an enduring challenge in the chemical synthesis of bioactive natural products
TL;DR: This review investigates the use of complex ester fragment couplings within natural product total synthesis campaigns and presents and discusses a collection of successful examples from the literature.
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Chemical activation of biochar for energy and environmental applications: a comprehensive review
TL;DR: In this article, a comprehensive overview on different chemical modification mechanisms and exploring their effects on Biochar physicochemical properties, functionalities, and applications is presented, where the nature of precursor materials, modification preparatory/conditions, and post-modification processes are considered in detail.
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Synthetic peptides analogous to the fimbrillin sequence inhibit adherence of Porphyromonas gingivalis.
TL;DR: The role and contribution of fimbriae in the binding of P. gingivalis to hydroxyapatite coated with saliva as a model for the pellicle-coated tooth surface and the observation that poly-L-lysine, bovine serum albumin, and defatted bovines serumalbumin, even at high concentrations, only partially blocked the binding, indicates that hydrophobic interactions are not the major forces involved in P.
References
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Journal ArticleDOI
The Use of Esters of N-Hydroxysuccinimide in Peptide Synthesis
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t-Butyl Esters of Amino Acids and Peptides and their Use in Peptide Synthesis1
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Zur Synthese des Glucagons, X. Darstellung der Sequenz 22–29
Erich Wünsch,Fritz Drees +1 more
TL;DR: In this paper, the geschutzte Teilsequenz 22-29 des Glucagons, wird auf zwei verschiedenen Wegen synthetisiert.