Journal ArticleDOI
Eine neue Methode zur Synthese von Peptiden: Aktivierung der Carboxylgruppe mit Dicyclohexylcarbodiimid unter Zusatz von 1‐Hydroxy‐benzotriazolen
Wolfgang König,Rolf Geiger +1 more
TLDR
In this article, the authors show that 1-Hydroxy-benzotriazol and 1-hydroxy-acetyl carbodiimid-methode eignen sich als Zusatze bei der Dicyclohexylcarbodiimids-Methode zur Synthese von Peptiden, verhindern die N-Acyl-harnstoffbildung and fuhren in hoher Ausbeute.Abstract:
1-Hydroxy-benzotriazol sowie verschiedene kernsubstituierte 1-Hydroxy-benzotriazole eignen sich als Zusatze bei der Dicyclohexylcarbodiimid-Methode zur Synthese von Peptiden. Ihr Einflus auf die Racemisierung bei Peptidsynthesen wurde unter Anwendung des gaschromatographischen Racemisierungstests von Weygand u. Mitarbb.2) untersucht. Die neuen Zusatze senken die Racemisierung, verhindern die N-Acyl-harnstoffbildung und fuhren in hoher Ausbeute zu sehr reinen Peptiden.read more
Citations
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Journal ArticleDOI
A Linear Multiporphyrinic [2]-Rotaxane via Amide Bond Formation
TL;DR: A linear multiporphyrinic [2]-rotaxane has been synthesized using the transition metal-templating method for threading a gold(III)-incorporating macrocycle onto a rodlike, phenanthroline-derived carboxylate end groups as mentioned in this paper.
Journal ArticleDOI
4-N-acylfortimicins B and the preparation of fortimicin A from fortimicin B.
TL;DR: The key intermediate, 1,2',6'-tri-N-benzyloxycarbonylfortimicin B, was prepared either directly from fortimICin B or by converting fortimic in A into 1,1,2,6',2''-tetra-n-benZyloxy CarbonylfORTimicIn A (6a), followed by selective hydrolysis of the 4-N-(N- Benzyl Oxycarbony
Journal ArticleDOI
Die Addition von Imidazolderivaten an DCCI; eine Nebenreaktion bei der Synthese von Histidinpeptiden
Hans Rink,Bernhard Riniker +1 more
TL;DR: In this paper, the reaction of imidazoles with DCCI leading to such compounds and their cleavage have been investigated, and the significance of this side-reaction in peptide synthesis is discussed.
Journal ArticleDOI
Anti-fibronectin antibodies that modify heparin binding and cell adhesion: evidence for a new cell binding site in the heparin binding region.
TL;DR: Melanoma cellular receptor(s) for the Hep II region may be cell surface proteoglycans but do not appear to bind to areas of Hep II with high affinity for soluble heparin, as the latter was not an inhibitor of B16 cell adhesion to the HBF.
Journal ArticleDOI
Synthesis of Somatostatin. Preliminary communication
TL;DR: A tetradecapeptide with the proposed structure of growth hormone release inhibiting factor was synthesized by a classical fragment approach as discussed by the authors, which was used to synthesize a growth hormone inhibitant.
References
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Journal ArticleDOI
The Use of Esters of N-Hydroxysuccinimide in Peptide Synthesis
Journal ArticleDOI
t-Butyl Esters of Amino Acids and Peptides and their Use in Peptide Synthesis1
Journal ArticleDOI
Zur Synthese des Glucagons, X. Darstellung der Sequenz 22–29
Erich Wünsch,Fritz Drees +1 more
TL;DR: In this paper, the geschutzte Teilsequenz 22-29 des Glucagons, wird auf zwei verschiedenen Wegen synthetisiert.