Journal ArticleDOI
Eine neue Methode zur Synthese von Peptiden: Aktivierung der Carboxylgruppe mit Dicyclohexylcarbodiimid unter Zusatz von 1‐Hydroxy‐benzotriazolen
Wolfgang König,Rolf Geiger +1 more
TLDR
In this article, the authors show that 1-Hydroxy-benzotriazol and 1-hydroxy-acetyl carbodiimid-methode eignen sich als Zusatze bei der Dicyclohexylcarbodiimids-Methode zur Synthese von Peptiden, verhindern die N-Acyl-harnstoffbildung and fuhren in hoher Ausbeute.Abstract:
1-Hydroxy-benzotriazol sowie verschiedene kernsubstituierte 1-Hydroxy-benzotriazole eignen sich als Zusatze bei der Dicyclohexylcarbodiimid-Methode zur Synthese von Peptiden. Ihr Einflus auf die Racemisierung bei Peptidsynthesen wurde unter Anwendung des gaschromatographischen Racemisierungstests von Weygand u. Mitarbb.2) untersucht. Die neuen Zusatze senken die Racemisierung, verhindern die N-Acyl-harnstoffbildung und fuhren in hoher Ausbeute zu sehr reinen Peptiden.read more
Citations
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Synthesis of substance P via its sulfoxide by the repetitive excess mixed anhydride (REMA) method
E. Izeboud,H. C. Beyerman +1 more
TL;DR: The N-protected heptapeptide sulfoxide corresponding to positions 5 to 11 inclusive of substance P was synthesized by the repetitive excess mixed anhydride (REMA) method (Scheme).
Journal ArticleDOI
Synthesis of racemic 3-methylphosphonate analogues of myo-inositol 3,4-bis- and 1,3,4-trisphosphate
TL;DR: The partially benzyl protected myo-inositol derivatives 11a and 11b were readily converted into the respective title compounds 18a and 18b by sequential methylphosphonylation, mild cleavage of the trans-prop-1-enyl group(s), phosphorylation and removal of all permanent benzyl protecting groups as mentioned in this paper.
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2-alkoxy-5 (4h) -oxazolones and the enantiomerization of n-alkoxycarbonylamino acids
TL;DR: In the presence of tert.amine (tertiary amine), most activated N-alkoxy-5(4H)-oxazolone is not chirally stable.
Journal ArticleDOI
Synthesis and Application of N‐Hydroxylamine Derivatives as Potential Replacements for HOBt
TL;DR: Albericio et al. as discussed by the authors presented an analysis of the relationship between organic chemistry and nanomedicine and showed that organic chemistry is a promising area of research in bioengineering.
Journal ArticleDOI
Solid-phase peptide synthesis in water. Part 3: A water-soluble N-protecting group, 2-[phenyl(methyl)sulfonio]ethoxycarbonyl tetrafluoroborate, and its application to solid phase peptide synthesis in water
TL;DR: In this paper, a water-soluble N-protecting group, 2-[phenyl(methyl)sulfonio]ethoxycarbonyl (Pms), was introduced to amino acids.
References
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Journal ArticleDOI
The Use of Esters of N-Hydroxysuccinimide in Peptide Synthesis
Journal ArticleDOI
t-Butyl Esters of Amino Acids and Peptides and their Use in Peptide Synthesis1
Journal ArticleDOI
Zur Synthese des Glucagons, X. Darstellung der Sequenz 22–29
Erich Wünsch,Fritz Drees +1 more
TL;DR: In this paper, the geschutzte Teilsequenz 22-29 des Glucagons, wird auf zwei verschiedenen Wegen synthetisiert.