Journal ArticleDOI
Eine neue Methode zur Synthese von Peptiden: Aktivierung der Carboxylgruppe mit Dicyclohexylcarbodiimid unter Zusatz von 1‐Hydroxy‐benzotriazolen
Wolfgang König,Rolf Geiger +1 more
TLDR
In this article, the authors show that 1-Hydroxy-benzotriazol and 1-hydroxy-acetyl carbodiimid-methode eignen sich als Zusatze bei der Dicyclohexylcarbodiimids-Methode zur Synthese von Peptiden, verhindern die N-Acyl-harnstoffbildung and fuhren in hoher Ausbeute.Abstract:
1-Hydroxy-benzotriazol sowie verschiedene kernsubstituierte 1-Hydroxy-benzotriazole eignen sich als Zusatze bei der Dicyclohexylcarbodiimid-Methode zur Synthese von Peptiden. Ihr Einflus auf die Racemisierung bei Peptidsynthesen wurde unter Anwendung des gaschromatographischen Racemisierungstests von Weygand u. Mitarbb.2) untersucht. Die neuen Zusatze senken die Racemisierung, verhindern die N-Acyl-harnstoffbildung und fuhren in hoher Ausbeute zu sehr reinen Peptiden.read more
Citations
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Orthogonal solid‐phase synthesis of human gastrin‐I under mild conditions
TL;DR: An approach to the solid-phase segment condensation synthesis of the 17-peptide amide human gastrin-I has been developed, and results compare favorably with those from a stepwise assembly.
Journal ArticleDOI
Synthesis and polymerization of functionalized dendritic macromonomers
TL;DR: In this article, the synthesis of dendritic building blocks (dendrons) of the first generation and the second generation, which carry differently protected amine groups in the periphery, is reported.
Journal ArticleDOI
Lithium‐Salt Effects in Peptide Synthesis. Part I. Conditions for the Use of Lithium‐Salts in Coupling Reactions
TL;DR: In this paper, the influence of Li-salts on the course of peptide-coupling reactions was investigated, and the effects of salt additives such as LiCl, LiBr, LiClO 4, and ZnCl 2 on yields, sideproduct formation, racemisation, and reaction rates were reported.
Journal ArticleDOI
Synthesis and Application of Hexamethyl-1,1'-spirobiindane-Based Phosphine-Oxazoline Ligands in Ni-Catalyzed Asymmetric Arylation of Cyclic Aldimines.
Sun Weiye,Gu Haorui,Xufeng Lin +2 more
TL;DR: A new type of chiral PHOX ligands based on a hexamethyl-1,1'-spirobiindane scaffold and incorporating both a phosphine and an oxazoline moiety are described, providing high yields and excellent enantioselectivities for Ni-catalyzed asymmetric arylation of cyclic N-sulfonyl imines with arylboronic acids leading to chiral amines.
Journal ArticleDOI
Synthese von Humaninsulin. II. Aufbau des cyclischen Fragments A(1–13)†‡
TL;DR: In this paper, a detailed account of the synthesis of the protected tridecapeptide A(1-13), BocGlyIleValGlu(OBut)Gln Ser(But)LeuOH (20), an essential intermediate in the recently published total synthesis of human insulin, is given.
References
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Journal ArticleDOI
The Use of Esters of N-Hydroxysuccinimide in Peptide Synthesis
Journal ArticleDOI
t-Butyl Esters of Amino Acids and Peptides and their Use in Peptide Synthesis1
Journal ArticleDOI
Zur Synthese des Glucagons, X. Darstellung der Sequenz 22–29
Erich Wünsch,Fritz Drees +1 more
TL;DR: In this paper, the geschutzte Teilsequenz 22-29 des Glucagons, wird auf zwei verschiedenen Wegen synthetisiert.