Journal ArticleDOI
Eine neue Methode zur Synthese von Peptiden: Aktivierung der Carboxylgruppe mit Dicyclohexylcarbodiimid unter Zusatz von 1‐Hydroxy‐benzotriazolen
Wolfgang König,Rolf Geiger +1 more
TLDR
In this article, the authors show that 1-Hydroxy-benzotriazol and 1-hydroxy-acetyl carbodiimid-methode eignen sich als Zusatze bei der Dicyclohexylcarbodiimids-Methode zur Synthese von Peptiden, verhindern die N-Acyl-harnstoffbildung and fuhren in hoher Ausbeute.Abstract:
1-Hydroxy-benzotriazol sowie verschiedene kernsubstituierte 1-Hydroxy-benzotriazole eignen sich als Zusatze bei der Dicyclohexylcarbodiimid-Methode zur Synthese von Peptiden. Ihr Einflus auf die Racemisierung bei Peptidsynthesen wurde unter Anwendung des gaschromatographischen Racemisierungstests von Weygand u. Mitarbb.2) untersucht. Die neuen Zusatze senken die Racemisierung, verhindern die N-Acyl-harnstoffbildung und fuhren in hoher Ausbeute zu sehr reinen Peptiden.read more
Citations
More filters
Journal ArticleDOI
Tetrahydrofuran amino acids: Secondary structure in tetrameric and octameric carbopeptoids derived from a D-allo 5-(aminomethyl)tetrahydrofuran-2-carboxylic acid.
Natasha L. Hungerford,Timothy D. W. Claridge,Mark P. Watterson,Robin T. Aplin,Andrés Moreno,George W. J. Fleet +5 more
TL;DR: In this article, the synthesis of a D-allo-5-(azidomethyl)tetrahydrofuran-2-carboxylate as an amino acid precursor is reported from D-ribose.
Journal ArticleDOI
Labeling of amino acids and peptides with isotopic oxygen as followed by 17O-N.M.R.
TL;DR: 17O-chemical shifts of synthetic intermediates and of the final products were as expected for each functional group, and Linewidth data correlate with the molecular weights of the compounds prepared.
Journal ArticleDOI
Total Synthesis of the α‐Helical Eicosapeptide Antibiotic Alamethicin
H. Schmitt,Günther Jung +1 more
TL;DR: The voltage-dependent membrane pore-forming polypeptide antibiotic alamethicin F 30 (Ac-Aib-Pro-Ala-Gly-Leu-Glu-Gln-Phl, 1) was synthesized by segment condensations as mentioned in this paper.
Journal ArticleDOI
Synthesis of Bicyclic Alkene-/Alkane-Bridged Nisin Mimics by Ring-Closing Metathesis and their Biochemical Evaluation as Lipid II Binders: toward the Design of Potential Novel Antibiotics
Nourdin Ghalit,Nourdin Ghalit,John F. Reichwein,Hans W. Hilbers,Eefjan Breukink,Dirk T. S. Rijkers,Rob M. J. Liskamp +6 more
TL;DR: It was found that these AB(C)‐ring mimics were not able to induce membrane leakage; however, they acted by inhibiting nisin‐induced carboxyfluorescein release; this indicates their affinity toward lipid II.
Journal ArticleDOI
Multiple peptide synthesis using a single support (MPS3)
Foe S. Tjoeng,Derek S. Towery,Joseph W. Bulock,Deborah E. Whipple,Kam F. Fok,Mark H. Williams,Mark E. Zupec,Steven Paul Adams +7 more
TL;DR: An automated multiple peptide synthesis method to synthesize, cleave, and purify several peptides simultaneously in a single batch has been developed and it has been found that DCC/HOBt gives the best coupling performance.
References
More filters
Journal ArticleDOI
The Use of Esters of N-Hydroxysuccinimide in Peptide Synthesis
Journal ArticleDOI
t-Butyl Esters of Amino Acids and Peptides and their Use in Peptide Synthesis1
Journal ArticleDOI
Zur Synthese des Glucagons, X. Darstellung der Sequenz 22–29
Erich Wünsch,Fritz Drees +1 more
TL;DR: In this paper, the geschutzte Teilsequenz 22-29 des Glucagons, wird auf zwei verschiedenen Wegen synthetisiert.