Journal ArticleDOI
Eine neue Methode zur Synthese von Peptiden: Aktivierung der Carboxylgruppe mit Dicyclohexylcarbodiimid unter Zusatz von 1‐Hydroxy‐benzotriazolen
Wolfgang König,Rolf Geiger +1 more
TLDR
In this article, the authors show that 1-Hydroxy-benzotriazol and 1-hydroxy-acetyl carbodiimid-methode eignen sich als Zusatze bei der Dicyclohexylcarbodiimids-Methode zur Synthese von Peptiden, verhindern die N-Acyl-harnstoffbildung and fuhren in hoher Ausbeute.Abstract:
1-Hydroxy-benzotriazol sowie verschiedene kernsubstituierte 1-Hydroxy-benzotriazole eignen sich als Zusatze bei der Dicyclohexylcarbodiimid-Methode zur Synthese von Peptiden. Ihr Einflus auf die Racemisierung bei Peptidsynthesen wurde unter Anwendung des gaschromatographischen Racemisierungstests von Weygand u. Mitarbb.2) untersucht. Die neuen Zusatze senken die Racemisierung, verhindern die N-Acyl-harnstoffbildung und fuhren in hoher Ausbeute zu sehr reinen Peptiden.read more
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A new silyl linker for reverse-direction solid-phase peptide synthesis
Bruce H. Lipshutz,Young-Jun Shin +1 more
TL;DR: In this paper, a free amino acid ester is treated with CO 2 followed by exposure to a chlorosilane-containing polystyrene, which results in its attachment to the solid support.
Journal ArticleDOI
Investigation of the diastereoisomeric association complex for the separation of amino acid enantiomers on optically active stationary phases
K. Grohmann,W. Parr +1 more
TL;DR: In this article, an N-acyl-amino acid n-alkyl amide (N-caproyl-L-valine n-hexyl amides) was synthesized, which fulfills the general requirements for the reversible association between the enantiomers and the asymmetric solvent molecules.
Journal Article
Amino acid derivatives. Part I. Synthesis, antiviral and antitumor evaluation of new alpha-amino acid esters bearing coumarin side chain.
Najim A. Al-Masoudi,Iman A. Al-Masoudi,Ibrahim A. I. Ali,Yaseen A. Al-Soud,Bahjat A. Saeed,Paolo La Colla +5 more
TL;DR: A series of amino acid esters bearing coumarin were synthesized and evaluated, in vitro, against HIV-1, and bovine viral diarrhea virus (BVDV) and exhibited activity against leukaemia (MT4) with CC50 = 24 micromol L(-1).
Journal ArticleDOI
Cyclization studies with a model pentapeptide
Ai-xue Ji,Miklos Bodanszky +1 more
TL;DR: Results of cyclization experiments carried out with a pentapeptide with the sequence Gly-Ala-D-Val-Leu-Ile suggest that separation of the steps of activation and coupling is preferable to cyclization with the help of coupling reagents.
Journal ArticleDOI
Synthesis of an insulin-like compound consisting of the A chain of insulin and a B chain corresponding to the B domain of human insulin-like growth factor I.
TL;DR: An insulin-like hybrid molecule consisting of the A chain of insulin and a B chain corresponding to the B domain of human insulin- like growth factor I (growth factor I sequence 1-30) has been synthesized essentially by the procedures developed in this laboratory for the synthesis of insulinand analogues.
References
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Journal ArticleDOI
The Use of Esters of N-Hydroxysuccinimide in Peptide Synthesis
Journal ArticleDOI
t-Butyl Esters of Amino Acids and Peptides and their Use in Peptide Synthesis1
Journal ArticleDOI
Zur Synthese des Glucagons, X. Darstellung der Sequenz 22–29
Erich Wünsch,Fritz Drees +1 more
TL;DR: In this paper, the geschutzte Teilsequenz 22-29 des Glucagons, wird auf zwei verschiedenen Wegen synthetisiert.