Journal ArticleDOI
Eine neue Methode zur Synthese von Peptiden: Aktivierung der Carboxylgruppe mit Dicyclohexylcarbodiimid unter Zusatz von 1‐Hydroxy‐benzotriazolen
Wolfgang König,Rolf Geiger +1 more
TLDR
In this article, the authors show that 1-Hydroxy-benzotriazol and 1-hydroxy-acetyl carbodiimid-methode eignen sich als Zusatze bei der Dicyclohexylcarbodiimids-Methode zur Synthese von Peptiden, verhindern die N-Acyl-harnstoffbildung and fuhren in hoher Ausbeute.Abstract:
1-Hydroxy-benzotriazol sowie verschiedene kernsubstituierte 1-Hydroxy-benzotriazole eignen sich als Zusatze bei der Dicyclohexylcarbodiimid-Methode zur Synthese von Peptiden. Ihr Einflus auf die Racemisierung bei Peptidsynthesen wurde unter Anwendung des gaschromatographischen Racemisierungstests von Weygand u. Mitarbb.2) untersucht. Die neuen Zusatze senken die Racemisierung, verhindern die N-Acyl-harnstoffbildung und fuhren in hoher Ausbeute zu sehr reinen Peptiden.read more
Citations
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Synthesis, biological activity and conformational analysis of cyclic GRF analogs.
Arthur Felix,Edgar P. Heimer,Ching-Tso Wang,Theodore Lambros,Alain Fournier,Thomas F. Mowles,S L Maines,Robert M. Campbell,Bogda Wegrzynski,Voldemar Toome,David C. Fry,Vincent S. Madison +11 more
TL;DR: Conformational analysis (circular dichroism and molecular dynamics calculations based on NOE-derived distance constraints) demonstrated that cyclo8,12[Asp8,Ala15]-GRF(1-29)-NH2 contains a long alpha-helical segment even in aqueous solution.
Journal ArticleDOI
Isolation and identification of a diuretic hormone from the tobacco hornworm, Manduca sexta.
Hiroshi Kataoka,Ruth G. Troetschler,Jorge P. Li,Steven J. Kramer,Robert L. Carney,David A. Schooley +5 more
TL;DR: Synthetic DH stimulated fluid excretion in vivo upon injection into larval M. sexta and newly emerged adult Pieris rapae and was synthesized and shown to have chromatographic and biological properties identical with those of the native material.
Journal ArticleDOI
Anticancer Agents, 15. Squaric Acid Diethyl Ester: A New Coupling Reagent for the Formation of Drug Biopolymer Conjugates. Synthesis of Squaric Acid Ester Amides and Diamides
Lutz F. Tietze,Michael Arlt,Matthias Beller,Karl‐Heinz Gl üsenkamp,Eckhard Jähde,Manfred F. Rajewsky +5 more
TL;DR: In this article, the reaction of squaric acid diethyl esters with a slight excess of a primary or secondary amine 2 in ethanol, dichloromethane or aqueous buffer (pH 7) at 20°C for 03-12 h was investigated.
Journal ArticleDOI
Fully defined in situ cross-linkable alginate and hyaluronic acid hydrogels for myocardial tissue engineering.
Julia Dahlmann,Andreas Krause,Lena Möller,George Kensah,Markus Möwes,Astrid Diekmann,Ulrich Martin,Andreas Kirschning,Ina Gruh,Gerald Dräger +9 more
TL;DR: In situ cross-linking hydrogels represent a valuable toolbox for the fine-tuning of engineered cardiac tissue's mechanical properties and improved functionality, facilitating clinical translation toward therapeutic heart muscle reconstruction.
Journal ArticleDOI
Large-scale synthesis of peptides.
TL;DR: This article focuses on chemical synthesis approaches for peptides, and presents an overview of the methods available and in use currently, together with a discussion of scale-up strategies.
References
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Journal ArticleDOI
The Use of Esters of N-Hydroxysuccinimide in Peptide Synthesis
Journal ArticleDOI
t-Butyl Esters of Amino Acids and Peptides and their Use in Peptide Synthesis1
Journal ArticleDOI
Zur Synthese des Glucagons, X. Darstellung der Sequenz 22–29
Erich Wünsch,Fritz Drees +1 more
TL;DR: In this paper, the geschutzte Teilsequenz 22-29 des Glucagons, wird auf zwei verschiedenen Wegen synthetisiert.