Journal ArticleDOI
Eine neue Methode zur Synthese von Peptiden: Aktivierung der Carboxylgruppe mit Dicyclohexylcarbodiimid unter Zusatz von 1‐Hydroxy‐benzotriazolen
Wolfgang König,Rolf Geiger +1 more
TLDR
In this article, the authors show that 1-Hydroxy-benzotriazol and 1-hydroxy-acetyl carbodiimid-methode eignen sich als Zusatze bei der Dicyclohexylcarbodiimids-Methode zur Synthese von Peptiden, verhindern die N-Acyl-harnstoffbildung and fuhren in hoher Ausbeute.Abstract:
1-Hydroxy-benzotriazol sowie verschiedene kernsubstituierte 1-Hydroxy-benzotriazole eignen sich als Zusatze bei der Dicyclohexylcarbodiimid-Methode zur Synthese von Peptiden. Ihr Einflus auf die Racemisierung bei Peptidsynthesen wurde unter Anwendung des gaschromatographischen Racemisierungstests von Weygand u. Mitarbb.2) untersucht. Die neuen Zusatze senken die Racemisierung, verhindern die N-Acyl-harnstoffbildung und fuhren in hoher Ausbeute zu sehr reinen Peptiden.read more
Citations
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Peptidkonformationen, 36 Konformationsuntersuchungen an vier cyclischen Heptapeptiden durch NMR‐Spektroskopie
Horst Kessler,Michael Bernd +1 more
TL;DR: In this paper, the synthesis and conformational analysis of four cyclic heptapeptides cyclo[Ala-Ile-Val-Ser(Bzl)-Xxx-Phe-Gly-] are presented.
Journal ArticleDOI
Exploring new dipeptides based on phenylglycine and Cα-methyl phenylglycine as hosts in inclusion resolutions
Simona Müller,Gerry J.A. Ariaans,Bernard Kaptein,Quirinus B. Broxterman,Fernando Formaggio,Elisa Battan,Marco Crisma,Claudio Toniolo,Alle Bruggink,Alle Bruggink +9 more
TL;DR: In this article, the 3D-structure of a hydrated (alphaMe)Phg dipeptide host was solved by single crystal X-ray diffraction and 12 homo-dipeptides derived from phenylglycine, Phg, and C-alpha-methyl phenyl glycine were synthesized and tested as resolving agents in resolutions through selective crystallization of inclusion compounds.
Journal ArticleDOI
Tertiäres Phosphan/Hexachlorethan als Kondensationsreagenz für die Peptidsynthese: Die Synthese von Bradykinin
Rolf Appel,Lothar Willms +1 more
Journal ArticleDOI
Modified method of synthesis of n-substituted dithioesters of amino acids and peptides in the pinner reaction
TL;DR: An improved method for the synthesis of dithioesters of amino acids and peptides has been developed and some novel dithIOesters, which are model compounds for resonance Raman spectroscopic studies of ditioacylpapain intermediates, are described.
Journal ArticleDOI
Studies of Unusual Amino Acids and Their Peptides. XVII. The Synthesis of Peptides Containing N-Carboxymethyl Amino Acids. II
TL;DR: The synthetic routes were investigated to four kinds of tetrapeptides made up of three usual amino acid residues and one N-carboxymethyl (Cm-) amino acid residue, and the efficiency of peptide bond formation at the imino group of a Cm-amino acid by the acid chloride method was remarkably improved under suitable reaction conditions.
References
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Journal ArticleDOI
The Use of Esters of N-Hydroxysuccinimide in Peptide Synthesis
Journal ArticleDOI
t-Butyl Esters of Amino Acids and Peptides and their Use in Peptide Synthesis1
Journal ArticleDOI
Zur Synthese des Glucagons, X. Darstellung der Sequenz 22–29
Erich Wünsch,Fritz Drees +1 more
TL;DR: In this paper, the geschutzte Teilsequenz 22-29 des Glucagons, wird auf zwei verschiedenen Wegen synthetisiert.