Journal ArticleDOI
Eine neue Methode zur Synthese von Peptiden: Aktivierung der Carboxylgruppe mit Dicyclohexylcarbodiimid unter Zusatz von 1‐Hydroxy‐benzotriazolen
Wolfgang König,Rolf Geiger +1 more
TLDR
In this article, the authors show that 1-Hydroxy-benzotriazol and 1-hydroxy-acetyl carbodiimid-methode eignen sich als Zusatze bei der Dicyclohexylcarbodiimids-Methode zur Synthese von Peptiden, verhindern die N-Acyl-harnstoffbildung and fuhren in hoher Ausbeute.Abstract:
1-Hydroxy-benzotriazol sowie verschiedene kernsubstituierte 1-Hydroxy-benzotriazole eignen sich als Zusatze bei der Dicyclohexylcarbodiimid-Methode zur Synthese von Peptiden. Ihr Einflus auf die Racemisierung bei Peptidsynthesen wurde unter Anwendung des gaschromatographischen Racemisierungstests von Weygand u. Mitarbb.2) untersucht. Die neuen Zusatze senken die Racemisierung, verhindern die N-Acyl-harnstoffbildung und fuhren in hoher Ausbeute zu sehr reinen Peptiden.read more
Citations
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Journal ArticleDOI
An exploration of the effects of L- and D-tetrahydroisoquinoline-3-carboxylic acid substitutions at positions 2, 3 and 7 in cyclic and linear antagonists of vasopressin and oxytocin and at position 3 in arginine vasopressin.
Maurice Manning,Ling Ling Cheng,Stoytcho Stoev,Krzysztof Bankowski,Jozef Przybyiski,Wieslaw A. Klis,Wilbur H. Sawyer,Nga Ching Wo,W. Y. Chan +8 more
TL;DR: L‐ and D‐Tic2 substitutions led to drastic losses of anti‐V2/anti‐V1a and anti‐oxytocic potencies in peptides 2, 4, 8 and 11 and the solid‐phase synthesis of peptide 10 together with the following Tic‐substituted peptides is reported.
Journal ArticleDOI
A Practical Enantioselective Synthesis of a Novel Peptide Deformylase Inhibitor
Joel Slade,David Thomas Parker,Michael J. Girgis,Martin Mueller,Vivelo James Anthony,Hui Liu,Joginder S. Bajwa,Guang-Pei Chen,Joseph Carosi,Paul G. Lee,Apurva Chaudhary,Dana Wambser,Kapa Prasad,Kathryn Rene Bracken,Karl Dean,Helmut Boehnke,Oljan Repic,Thomas J. Blacklock +17 more
TL;DR: In this article, the peptide deformylase inhibitor LBM415, (2S)-N-(5-fluoro-1-oxido-2-pyridinyl)-1-[(2R)-2]-(formylhydroxyamino)methyl]-1-(oxohexyl]-2pyrrolidinecarboxamide, magnesium salt, was described.
Journal ArticleDOI
Interaction of Cu(II) and Ni(II) with the 63–93 fragment of histone H2B
Kimon Zavitsanos,Ana Mónica Nunes,Gerasimos Malandrinos,Csilla Kállay,Imre Sóvágó,Vassiliki Magafa,Paul Cordopatis,Nick Hadjiliadis +7 more
TL;DR: Potentiometric and spectroscopic studies showed that histidine 21 acts as an anchoring binding site for the metal ion in Ac-NSFVNDIFERIAGEASRLAHYNKRSTITSRE-NH2.
Journal ArticleDOI
Solution synthesis of a dimeric pentapeptide: Diketopiperazine cyclisation of Glu-Asp dipeptide esters and Asp-racemisation during segment condensation
TL;DR: A haemoregulatory peptide analogue derived from the cystine-dimerised pentapeptide Glp-Glu-Asp-Cys-Lys-OH, in which the Cystine residue has been replaced by an isosteric L,L-2,7-diaminosuberic acid moiety, was prepared by segment condensation in solution.
Book ChapterDOI
Solid-phase peptide synthesis using microwave irradiation.
TL;DR: These microwave-assisted peptide synthesis procedures have been used to rapidly prepare a "difficult" peptide sequence from the acyl carrier protein, ACP(65-74), in less than 3 h and the reduced, linear precursor to human hepcidin, in high initial purity.
References
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Journal ArticleDOI
The Use of Esters of N-Hydroxysuccinimide in Peptide Synthesis
Journal ArticleDOI
t-Butyl Esters of Amino Acids and Peptides and their Use in Peptide Synthesis1
Journal ArticleDOI
Zur Synthese des Glucagons, X. Darstellung der Sequenz 22–29
Erich Wünsch,Fritz Drees +1 more
TL;DR: In this paper, the geschutzte Teilsequenz 22-29 des Glucagons, wird auf zwei verschiedenen Wegen synthetisiert.