Journal ArticleDOI
Eine neue Methode zur Synthese von Peptiden: Aktivierung der Carboxylgruppe mit Dicyclohexylcarbodiimid unter Zusatz von 1‐Hydroxy‐benzotriazolen
Wolfgang König,Rolf Geiger +1 more
TLDR
In this article, the authors show that 1-Hydroxy-benzotriazol and 1-hydroxy-acetyl carbodiimid-methode eignen sich als Zusatze bei der Dicyclohexylcarbodiimids-Methode zur Synthese von Peptiden, verhindern die N-Acyl-harnstoffbildung and fuhren in hoher Ausbeute.Abstract:
1-Hydroxy-benzotriazol sowie verschiedene kernsubstituierte 1-Hydroxy-benzotriazole eignen sich als Zusatze bei der Dicyclohexylcarbodiimid-Methode zur Synthese von Peptiden. Ihr Einflus auf die Racemisierung bei Peptidsynthesen wurde unter Anwendung des gaschromatographischen Racemisierungstests von Weygand u. Mitarbb.2) untersucht. Die neuen Zusatze senken die Racemisierung, verhindern die N-Acyl-harnstoffbildung und fuhren in hoher Ausbeute zu sehr reinen Peptiden.read more
Citations
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Journal ArticleDOI
Structure-Activity Relationship Studies of 3-epi-Deoxynegamycin Derivatives as Potent Readthrough Drug Candidates.
Keisuke Hamada,Akihiro Taguchi,Masaya Kotake,Suguru Aita,Saori Murakami,Kentaro Takayama,Fumika Yakushiji,Yoshio Hayashi +7 more
TL;DR: Results suggest that benzyl ester-type derivatives enhance the hydrophobicity and function as prodrugs to produce active compound 9b in living cell systems.
Journal ArticleDOI
Isotachophoretic analysis of the end-product and intermediates in the synthesis of the C-terminal pentapeptide of bombinin
TL;DR: The rapid and sensitive method of isotachophoresis should prove useful to the peptide chemist for assessment of his products, and for redesign or modification of non‐optimal synthetic strategies.
Journal ArticleDOI
Synthesis and structure revision of symplocin A
Shao Luping,Chang-Mei Si,Zhuo-Ya Mao,Wen Zhou,Tadeusz F. Molinski,Bang-Guo Wei,Guo-Qiang Lin +6 more
TL;DR: The stereochemistry of natural symplocin A was unambiguously revised through the confirmation by 1D NMR, 2D N MR, and HPLC comparisons with authentic natural product.
Journal ArticleDOI
Die Struktur von Stenothricin – Korrektur eines früheren Strukturvorschlags
TL;DR: In this paper, a deviation from the previously assumed molecular mass was proved by fast-atom bombardment mass-spectrometry for the peptide antibiotic stenothricin, which was found to contain α-ketobutyrylvaline formed by hydrolysis of an α,β-dehydroaminobutyric acid (DH-Abu) moiety.
Journal ArticleDOI
Synthesis and immunostimulant activity of novel analogs of human casein fragment (54-59)
R. Sahai,Anju Puri,Ram Prakash Saxena,Rahui Saran,Wahajul Haq,Bijoy Kundu,Krishna Bihar Mathur +6 more
TL;DR: Structural analogs of the hexapeptide sequence 54-59 (A) human casein, reported to stimulate immune response, were synthesized and evaluated for immunostimulant activity and induced higher stimulation of non-specific immune response.
References
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Journal ArticleDOI
The Use of Esters of N-Hydroxysuccinimide in Peptide Synthesis
Journal ArticleDOI
t-Butyl Esters of Amino Acids and Peptides and their Use in Peptide Synthesis1
Journal ArticleDOI
Zur Synthese des Glucagons, X. Darstellung der Sequenz 22–29
Erich Wünsch,Fritz Drees +1 more
TL;DR: In this paper, the geschutzte Teilsequenz 22-29 des Glucagons, wird auf zwei verschiedenen Wegen synthetisiert.