Journal ArticleDOI
Eine neue Methode zur Synthese von Peptiden: Aktivierung der Carboxylgruppe mit Dicyclohexylcarbodiimid unter Zusatz von 1‐Hydroxy‐benzotriazolen
Wolfgang König,Rolf Geiger +1 more
TLDR
In this article, the authors show that 1-Hydroxy-benzotriazol and 1-hydroxy-acetyl carbodiimid-methode eignen sich als Zusatze bei der Dicyclohexylcarbodiimids-Methode zur Synthese von Peptiden, verhindern die N-Acyl-harnstoffbildung and fuhren in hoher Ausbeute.Abstract:
1-Hydroxy-benzotriazol sowie verschiedene kernsubstituierte 1-Hydroxy-benzotriazole eignen sich als Zusatze bei der Dicyclohexylcarbodiimid-Methode zur Synthese von Peptiden. Ihr Einflus auf die Racemisierung bei Peptidsynthesen wurde unter Anwendung des gaschromatographischen Racemisierungstests von Weygand u. Mitarbb.2) untersucht. Die neuen Zusatze senken die Racemisierung, verhindern die N-Acyl-harnstoffbildung und fuhren in hoher Ausbeute zu sehr reinen Peptiden.read more
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Novel acylation catalysts in peptide synthesis: derivatives of N-hydroxytriazoles and N-hydroxytetrazoles
TL;DR: In this paper, six new derivatives of 1-hydroxy-1,2,3-triazole and N-hydroxtetrazole have been evaluated in a direct competition assay to investigate their efficiency as catalysts in the formation of peptide bonds.
Journal ArticleDOI
Synthesis of thymosin α1 by fragment condensation using tert.‐butyl side chain protection
Arthur Felix,Edgar P. Heimer,Ching-Tso Wang,Theodore Lambros,Joseph Swistok,Roszkowski M,Mushtaq Ahmad,Confalone D,Scott Jw,Parker D +9 more
TL;DR: A novel synthesis of thymosin alpha 1 by classical methods using seven tert.-butyl side chain protected fragments is described and the product was shown to be homogeneous by thin-layer and paper high voltage electrophoresis, isoelectric focusing analysis, thin- layer chromatography and high performance liquid chromatography.
Journal ArticleDOI
Darstellung, Charakterisierung und Konformationsbestimmung eines Undekapeptidhydrazids der N‐terminalen Alamethicin‐Sequenz
Wilfried Mayr,Günther Jung +1 more
TL;DR: The N-terminal, helical part 2 of the sequence of the polypeptide antibiotic alamethicin (1) was synthesized on polyoxyethylene as solubilizing support as mentioned in this paper.
Journal ArticleDOI
STUDIES ON PEPTIDES LXXXI. Application of a New Arginine Derivative, NG-Mesitylene-2-Sulfonylarginine, to the Synthesis of Substance P and Neurotensin
Haruaki Yajima,Kenichi Akaji,Kazuya Mitani,Nobutaka Fujii,Susumu Funakoshi,Hideki Adachi,Mariko Oishi,Yoshiharu Akazawa +7 more
TL;DR: A new devised arginine derivative, NG-mesitylene-2-sulfonylarginine, Arg(Mts), was employed for the synthesis of hypothalamic substance P and neurotensin.
Journal ArticleDOI
Fmoc-based solid-phase peptide synthesis using a new t-alcohol type 4-(1′,1′-dimethyl-1′-hydroxypropyl)phenoxyacetyl handle (DHPP)–resin (Fmoc = fluoren-9-ylmethoxycarbonyl)
TL;DR: In this article, the loss of C-terminal dipeptide through diketopiperazine formation during Fmoc-based solid phase peptide synthesis has been effectively suppressed by anchoring the first fmoc amino acid chloride to a new 4-(1′, 1′-dimethyl-1′-hydroxypropyl)phenoxyacetyl handle (DHPP)-resin; this new t-alcohol type DHPP-resin has been successfully applied to the solid phase synthesis of bradykinin potentiator B (an eleven-rersid
References
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Journal ArticleDOI
The Use of Esters of N-Hydroxysuccinimide in Peptide Synthesis
Journal ArticleDOI
t-Butyl Esters of Amino Acids and Peptides and their Use in Peptide Synthesis1
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Zur Synthese des Glucagons, X. Darstellung der Sequenz 22–29
Erich Wünsch,Fritz Drees +1 more
TL;DR: In this paper, the geschutzte Teilsequenz 22-29 des Glucagons, wird auf zwei verschiedenen Wegen synthetisiert.