Journal ArticleDOI
Eine neue Methode zur Synthese von Peptiden: Aktivierung der Carboxylgruppe mit Dicyclohexylcarbodiimid unter Zusatz von 1‐Hydroxy‐benzotriazolen
Wolfgang König,Rolf Geiger +1 more
TLDR
In this article, the authors show that 1-Hydroxy-benzotriazol and 1-hydroxy-acetyl carbodiimid-methode eignen sich als Zusatze bei der Dicyclohexylcarbodiimids-Methode zur Synthese von Peptiden, verhindern die N-Acyl-harnstoffbildung and fuhren in hoher Ausbeute.Abstract:
1-Hydroxy-benzotriazol sowie verschiedene kernsubstituierte 1-Hydroxy-benzotriazole eignen sich als Zusatze bei der Dicyclohexylcarbodiimid-Methode zur Synthese von Peptiden. Ihr Einflus auf die Racemisierung bei Peptidsynthesen wurde unter Anwendung des gaschromatographischen Racemisierungstests von Weygand u. Mitarbb.2) untersucht. Die neuen Zusatze senken die Racemisierung, verhindern die N-Acyl-harnstoffbildung und fuhren in hoher Ausbeute zu sehr reinen Peptiden.read more
Citations
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Journal ArticleDOI
Antidiuretic and pressor activities of vasopressin analogs with L-alaninamide and D-alaninamide substitutions at position 9.
TL;DR: It is shown that the antidiuretic receptor will tolerate considerably more structural alteration in the C-terminal tripeptide "tail" of the vasopressins than will the pressor receptor.
Journal ArticleDOI
A model reaction for assessing the coupling and chiral efficiency of reagents in depside bond formation
TL;DR: In this article, HPLC analysis for a number of coupling conditions between Fmoc-L-AIa-OH and H-Phlac-OBzl has been performed and it is revealed that CDI, DCC/DMAP and mixed anhydride couplings gave yields near to 50%.
Journal ArticleDOI
A mechanistic study of the rearrangement of 1-benzoyloxybenzotriazoles to 3-benzoylbenzotriazole 1-oxides
TL;DR: Crossover experiments demonstrate that the title rearrangement processes are intermolecular as discussed by the authors, which is consistent with the results of our experiments, and they also support our results.
Journal ArticleDOI
Efficient activity of magnesium–aluminium hydrotalcite in the synthesis of amides
José Antonio Morales-Serna,Miguel Ángel Jaime-Vasconcelos,Eréndira García-Ríos,Alejandro Canales Cruz,Deyanira Angeles-Beltrán,Leticia Lomas-Romero,Guillermo E. Negrón-Silva,Jorge Cárdenas +7 more
TL;DR: In this article, the synthesis of amides by coupling benzotriazole esters and amines can be achieved conveniently in moderate to excellent yields (50-95%) using a commercial, synthesized, calcined or reconstructed Mg-Al hydrotalcite instead of one of the classic bases (tertiary amines).
Journal ArticleDOI
Synthesis and biological properties of polymer immunoadjuvants
TL;DR: The preliminary results show that, when measuring the serum antibody response to SjAg in female mice over 10 weeks, the polyphosphate (I) exhibited strong adjuvant activity.
References
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Journal ArticleDOI
The Use of Esters of N-Hydroxysuccinimide in Peptide Synthesis
Journal ArticleDOI
t-Butyl Esters of Amino Acids and Peptides and their Use in Peptide Synthesis1
Journal ArticleDOI
Zur Synthese des Glucagons, X. Darstellung der Sequenz 22–29
Erich Wünsch,Fritz Drees +1 more
TL;DR: In this paper, the geschutzte Teilsequenz 22-29 des Glucagons, wird auf zwei verschiedenen Wegen synthetisiert.