Journal ArticleDOI
Eine neue Methode zur Synthese von Peptiden: Aktivierung der Carboxylgruppe mit Dicyclohexylcarbodiimid unter Zusatz von 1‐Hydroxy‐benzotriazolen
Wolfgang König,Rolf Geiger +1 more
TLDR
In this article, the authors show that 1-Hydroxy-benzotriazol and 1-hydroxy-acetyl carbodiimid-methode eignen sich als Zusatze bei der Dicyclohexylcarbodiimids-Methode zur Synthese von Peptiden, verhindern die N-Acyl-harnstoffbildung and fuhren in hoher Ausbeute.Abstract:
1-Hydroxy-benzotriazol sowie verschiedene kernsubstituierte 1-Hydroxy-benzotriazole eignen sich als Zusatze bei der Dicyclohexylcarbodiimid-Methode zur Synthese von Peptiden. Ihr Einflus auf die Racemisierung bei Peptidsynthesen wurde unter Anwendung des gaschromatographischen Racemisierungstests von Weygand u. Mitarbb.2) untersucht. Die neuen Zusatze senken die Racemisierung, verhindern die N-Acyl-harnstoffbildung und fuhren in hoher Ausbeute zu sehr reinen Peptiden.read more
Citations
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Journal ArticleDOI
Synthesis and analgesic activity of human beta-endorphin analogs substituted at positions 17, 18, or 19.
TL;DR: Three peptide analogs of beta-endorphin which are substituted in positions 17, 18 or 19 have been synthesized and their analgesic potencies have been measured by the tail-flick method in mice and showed that the replacement of Phe-18 or Lys-19 by alanine reduced the potency.
Journal ArticleDOI
Some sulfonates of strongly acidic N-hydroxy compounds as novel coupling reagents
Journal ArticleDOI
In-situ investigation of superplasticizers: From fluorescence microscopy to concrete rheology
TL;DR: In this paper, a method to investigate the interaction of superplasticizers with mineral particles is presented, based on the application of fluorescence microscopy, which enables the first time to localize and quantify the adsorption of super-plasticizer to particles and to vary experimental parameters during measurement.
Journal ArticleDOI
[1,6-alpha-aminosuberic acid, 3-(p-azidophenylalanine), 8-arginine] vasopressin: a new photoaffinity label for hydroosmotic hormone receptors. Characterization of the ligand and irreversible stimulation of hydroosmotic water flow in toad bladder by photoaffinity labeling.
TL;DR: Findings indicate that with photoactivation [Asu1,6, Phe(p-N3)3]AVP binds covalently to hormonal receptors and forms an active hormone-receptor complex and is a suitable tool for studies of hydroosmotic receptor function and for receptor isolation.
Book ChapterDOI
The Mixed Carbonic Anhydride Method of Peptide Synthesis
TL;DR: This chapter describes the mixed carbonic anhydride method of peptide synthesis, which is not very sensitive to the nature of the solvent, but it is prone to a few side reactions, of which only the formation of a second acylation product by attack of the amine component at the carbonic acid carbonyl is of practical concern.
References
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Journal ArticleDOI
The Use of Esters of N-Hydroxysuccinimide in Peptide Synthesis
Journal ArticleDOI
t-Butyl Esters of Amino Acids and Peptides and their Use in Peptide Synthesis1
Journal ArticleDOI
Zur Synthese des Glucagons, X. Darstellung der Sequenz 22–29
Erich Wünsch,Fritz Drees +1 more
TL;DR: In this paper, the geschutzte Teilsequenz 22-29 des Glucagons, wird auf zwei verschiedenen Wegen synthetisiert.