Journal ArticleDOI
Eine neue Methode zur Synthese von Peptiden: Aktivierung der Carboxylgruppe mit Dicyclohexylcarbodiimid unter Zusatz von 1‐Hydroxy‐benzotriazolen
Wolfgang König,Rolf Geiger +1 more
TLDR
In this article, the authors show that 1-Hydroxy-benzotriazol and 1-hydroxy-acetyl carbodiimid-methode eignen sich als Zusatze bei der Dicyclohexylcarbodiimids-Methode zur Synthese von Peptiden, verhindern die N-Acyl-harnstoffbildung and fuhren in hoher Ausbeute.Abstract:
1-Hydroxy-benzotriazol sowie verschiedene kernsubstituierte 1-Hydroxy-benzotriazole eignen sich als Zusatze bei der Dicyclohexylcarbodiimid-Methode zur Synthese von Peptiden. Ihr Einflus auf die Racemisierung bei Peptidsynthesen wurde unter Anwendung des gaschromatographischen Racemisierungstests von Weygand u. Mitarbb.2) untersucht. Die neuen Zusatze senken die Racemisierung, verhindern die N-Acyl-harnstoffbildung und fuhren in hoher Ausbeute zu sehr reinen Peptiden.read more
Citations
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Journal ArticleDOI
Synthesis and characterization of chiral stationary phases from amino acids and small peptides for liquid chromatography fractionations of a racemic alcohol
TL;DR: A series of amino acid and dipeptide bonded phases have been prepared and the performances of these chiral stationary phases for separation of R,S -2,2, 2-trifluoro-1-(9-anthryl)ethanol have been examined as discussed by the authors.
Patent
Halogen-substituted compounds
Michael Maue,Isabelle Adelt,Wolfgang Giencke,Markus Heil,Peter Jeschke,Bernd-Wieland Krüger,Friedrich August Mühlthau,Alexander Sudau,Klaus Raming,Ulrich Ebbinghaus-Kintscher,Martin Adamczewski,Arnd Voerste,Ulrich Görgens,Tobias Kapferer,Mark Wilhelm Drewes,Angela Becker,Eva-Maria Franken +16 more
TL;DR: In this paper, a general formula for controlling insects, arachnids and nematodes in agriculture and ectoparasites in veterinary medicine has been described, and processes for preparing the compounds of the formula are described.
Journal ArticleDOI
Chemoenzymatic synthesis of iminocyclitol derivatives: A useful library strategy for the development of selective fucosyltransfer enzymes inhibitors
TL;DR: A chemoenzymatic strategy has been developed for the synthesis of libraries of iminocyclitol derivatives for the discovery of new and selective fucosidase inhibitors.
Journal ArticleDOI
Synthetic studies towards diazepanone scaffolds
Olivier Monasson,Maryon Ginisty,Janez Mravljak,Gildas Bertho,Christine Gravier-Pelletier,Yves Le Merrer +5 more
TL;DR: The synthesis of new enantiopure polyfunctionalised diazepanone scaffolds is described and the key steps involve the opening of an azido-epoxide C4 building block derived from l -ascorbic or d -isoASCorbic acid by a l -serine derivative followed by a lactonisation–lactamisation two-step sequence.
Book ChapterDOI
Solid-phase peptide synthesis: an introduction.
TL;DR: This chapter provides an introduction to and overview of peptide chemistry with a focus on solid-phase peptide synthesis and points to the different chapters and puts them into perspective.
References
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Journal ArticleDOI
The Use of Esters of N-Hydroxysuccinimide in Peptide Synthesis
Journal ArticleDOI
t-Butyl Esters of Amino Acids and Peptides and their Use in Peptide Synthesis1
Journal ArticleDOI
Zur Synthese des Glucagons, X. Darstellung der Sequenz 22–29
Erich Wünsch,Fritz Drees +1 more
TL;DR: In this paper, the geschutzte Teilsequenz 22-29 des Glucagons, wird auf zwei verschiedenen Wegen synthetisiert.