Journal ArticleDOI
Eine neue Methode zur Synthese von Peptiden: Aktivierung der Carboxylgruppe mit Dicyclohexylcarbodiimid unter Zusatz von 1‐Hydroxy‐benzotriazolen
Wolfgang König,Rolf Geiger +1 more
TLDR
In this article, the authors show that 1-Hydroxy-benzotriazol and 1-hydroxy-acetyl carbodiimid-methode eignen sich als Zusatze bei der Dicyclohexylcarbodiimids-Methode zur Synthese von Peptiden, verhindern die N-Acyl-harnstoffbildung and fuhren in hoher Ausbeute.Abstract:
1-Hydroxy-benzotriazol sowie verschiedene kernsubstituierte 1-Hydroxy-benzotriazole eignen sich als Zusatze bei der Dicyclohexylcarbodiimid-Methode zur Synthese von Peptiden. Ihr Einflus auf die Racemisierung bei Peptidsynthesen wurde unter Anwendung des gaschromatographischen Racemisierungstests von Weygand u. Mitarbb.2) untersucht. Die neuen Zusatze senken die Racemisierung, verhindern die N-Acyl-harnstoffbildung und fuhren in hoher Ausbeute zu sehr reinen Peptiden.read more
Citations
More filters
Journal ArticleDOI
Nebenreaktionen bei der Festphasensynthese von Peptiden, IV1) Intrachenare und interchenare Aminolyse der Benzylesterbindung zum polymeren Träger und ihre Auswirkungen
Manfred Rothe,Jan Mazánek +1 more
TL;DR: In this paper, the interchenare Aminolyse fuhrt zu verlangerten Peptidsequenzen, and the corresponding intra-chain aminolysis, and undesired esterification of the polymer-bound hydroxymethyl groups formed during these reactions on the resin (with the Boc-amino acids2) and dicyclohexyl carbodiimide) during subsequent chain lengthening steps.
Journal ArticleDOI
Surface Properties of Water-Soluble Glycine-Cysteamine-Protected Gold Clusters
TL;DR: The synthesis of water-soluble, nearly monodisperse glycine-cysteamine gold monolayer protected clusters (MPCs) via base deprotection of Fmoc-Gly-CSA MPCs shows that amine-terminated MPCs can be synthesized; however, their aggregation at intermediate pH's can limit their utility as building blocks for multifunctional nanoparticle syntheses.
Journal ArticleDOI
The influence of the side-chain sequence on the structure-activity correlations of immunomodulatory branched polypeptides. Synthesis and conformational analysis of new model polypeptides.
TL;DR: New branched polypeptides were synthesized for a detailed study of the influence of the side‐chain structure on the conformation and biological properties.
Journal ArticleDOI
Synthesis of sequential polypeptides containing L-β-3,4-dihydroxyphenyl-α-alanine (DOPA) and L-lysine
Hiroyuki Yamamoto,Tadao Hayakawa +1 more
TL;DR: Water‐soluble sequential polypeptides containing L‐DOPA were obtained and the addition of 1‐hydroxybenzotriazole increased their molecular weights, but not so effectively.
Journal ArticleDOI
Asymmetric synthesis of 34--substituted β-lactams via chiral norephedrine-derived oxazolidines.
TL;DR: A diastereo and enantioselective approach to functionalized 3,4- cis -β-lactams 9 and 16 was developed based on the use of chiral norephedrine-derived oxazolidines as mentioned in this paper.
References
More filters
Journal ArticleDOI
The Use of Esters of N-Hydroxysuccinimide in Peptide Synthesis
Journal ArticleDOI
t-Butyl Esters of Amino Acids and Peptides and their Use in Peptide Synthesis1
Journal ArticleDOI
Zur Synthese des Glucagons, X. Darstellung der Sequenz 22–29
Erich Wünsch,Fritz Drees +1 more
TL;DR: In this paper, the geschutzte Teilsequenz 22-29 des Glucagons, wird auf zwei verschiedenen Wegen synthetisiert.