Journal ArticleDOI
Eine neue Methode zur Synthese von Peptiden: Aktivierung der Carboxylgruppe mit Dicyclohexylcarbodiimid unter Zusatz von 1‐Hydroxy‐benzotriazolen
Wolfgang König,Rolf Geiger +1 more
TLDR
In this article, the authors show that 1-Hydroxy-benzotriazol and 1-hydroxy-acetyl carbodiimid-methode eignen sich als Zusatze bei der Dicyclohexylcarbodiimids-Methode zur Synthese von Peptiden, verhindern die N-Acyl-harnstoffbildung and fuhren in hoher Ausbeute.Abstract:
1-Hydroxy-benzotriazol sowie verschiedene kernsubstituierte 1-Hydroxy-benzotriazole eignen sich als Zusatze bei der Dicyclohexylcarbodiimid-Methode zur Synthese von Peptiden. Ihr Einflus auf die Racemisierung bei Peptidsynthesen wurde unter Anwendung des gaschromatographischen Racemisierungstests von Weygand u. Mitarbb.2) untersucht. Die neuen Zusatze senken die Racemisierung, verhindern die N-Acyl-harnstoffbildung und fuhren in hoher Ausbeute zu sehr reinen Peptiden.read more
Citations
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Determining the occurrence of a 3(10)-helix and an alpha-helix in two different segments of a lipopeptaibol antibiotic using TOAC, a nitroxide spin-labeled C(alpha)-tetrasubstituted alpha-aminoacid.
Vania Monaco,Fernando Formaggio,Marco Crisma,Claudio Toniolo,Paul Hanson,Glenn L. Millhauser,Clifford George,Jeffrey R. Deschamps,Judith L. Flippen-Anderson +8 more
TL;DR: It is concluded that the secondary structure in solution remains essentially unchanged if compared to that previously found in the crystal state for trichogin, while the N-terminal region of the peptide folds in a 3(10)-helix, which is mainly alpha-helical.
Journal ArticleDOI
Peptide synthesis beyond DMF: THF and ACN as excellent and friendlier alternatives
Yahya E. Jad,Gerardo A. Acosta,Sherine N. Khattab,Beatriz G. de la Torre,Thavendran Govender,Hendrik G. Kruger,Ayman El-Faham,Ayman El-Faham,Fernando Albericio +8 more
TL;DR: THF and ACN are demonstrated to have a better coupling efficiency than DMF in the solid-phase peptide synthesis of hindered peptides and in combination with a complete polyethylene glycol resin (ChemMatrix).
Journal ArticleDOI
Platinum Porphyrins as Phosphorescent Label for Time-resolved Microscopy:
R. R. De Haas,R.P.M. van Gijlswijk,E. B. Van Der Tol,H. J. M. A. A. Zijlmans,T. Bakker-Schut,J. Bonnet,N. P. Verwoerd,H. J. Tanke +7 more
TL;DR: Applications of time-resolved detection of phosphorescent porphyrins in strongly autofluorescent material (histological sections) are discussed.
Journal ArticleDOI
Supramolecular dendrimer chemistry: using dendritic crown ethers to reversibly generate functional assemblies
Graham M. Dykes,David K. Smith +1 more
TL;DR: In this article, a series of crown ether derivatives functionalised with dendritic branching based on l -lysine repeat units has been synthesised, and the ability of these receptors to interact with cationic guests has been investigated using NMR and mass spectrometric techniques.
Journal ArticleDOI
2-Methyltetrahydrofuran and cyclopentyl methyl ether for green solid-phase peptide synthesis
Yahya E. Jad,Gerardo A. Acosta,Sherine N. Khattab,Beatriz G. de la Torre,Thavendran Govender,Hendrik G. Kruger,Ayman El-Faham,Ayman El-Faham,Fernando Albericio +8 more
TL;DR: The use of 2-MeTHF with combination of DIC/OxymaPure gave the lowest racemization level during stepwise synthesis of Z-Phg-Pro-NH2 and the highest purity during SPPS of Aib-enkephalin pentapeptide.
References
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Journal ArticleDOI
The Use of Esters of N-Hydroxysuccinimide in Peptide Synthesis
Journal ArticleDOI
t-Butyl Esters of Amino Acids and Peptides and their Use in Peptide Synthesis1
Journal ArticleDOI
Zur Synthese des Glucagons, X. Darstellung der Sequenz 22–29
Erich Wünsch,Fritz Drees +1 more
TL;DR: In this paper, the geschutzte Teilsequenz 22-29 des Glucagons, wird auf zwei verschiedenen Wegen synthetisiert.