Journal ArticleDOI
Eine neue Methode zur Synthese von Peptiden: Aktivierung der Carboxylgruppe mit Dicyclohexylcarbodiimid unter Zusatz von 1‐Hydroxy‐benzotriazolen
Wolfgang König,Rolf Geiger +1 more
TLDR
In this article, the authors show that 1-Hydroxy-benzotriazol and 1-hydroxy-acetyl carbodiimid-methode eignen sich als Zusatze bei der Dicyclohexylcarbodiimids-Methode zur Synthese von Peptiden, verhindern die N-Acyl-harnstoffbildung and fuhren in hoher Ausbeute.Abstract:
1-Hydroxy-benzotriazol sowie verschiedene kernsubstituierte 1-Hydroxy-benzotriazole eignen sich als Zusatze bei der Dicyclohexylcarbodiimid-Methode zur Synthese von Peptiden. Ihr Einflus auf die Racemisierung bei Peptidsynthesen wurde unter Anwendung des gaschromatographischen Racemisierungstests von Weygand u. Mitarbb.2) untersucht. Die neuen Zusatze senken die Racemisierung, verhindern die N-Acyl-harnstoffbildung und fuhren in hoher Ausbeute zu sehr reinen Peptiden.read more
Citations
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Solid-phase synthesis of cecropin A and related peptides.
TL;DR: Cecropin A, a 37-residue antibacterial peptide amide, was synthesized by the solid-phase method and was shown to be homogeneous and totally indistinguishable from natural cecropIn A by chemical and physical criteria, as well as by its antibacterial activity against several Gram-positive and Gram-negative organisms.
Journal ArticleDOI
A new approach to the synthesis of phosphotriester intermediates of nucleosides and nucleic acids
TL;DR: Aryl phosphorodichloridates can be converted by means of 1-hydroxybenzotriazole into an effective phosphorylating agent, which can be applied to the synthesis of phosphotriester intermediates of nucleic acids as mentioned in this paper.
Journal ArticleDOI
Corticotropin-releasing factor modulates the immune response to stress in the rat.
Rajeev Jain,Don Zwickler,Charles S. Hollander,Howard Brand,Arnold Saperstein,Brian Hutchinson,Cynthia Brown,Tapan Audhya +7 more
TL;DR: It is indicated that CRF plays a significant role in modulating the immune response to subacute stress, largely by adrenal-independent mechanisms, and administration of exogenous CRF resulted in significant decrements in lymphocyte proliferation and natural killer cytotoxicity, similar to those seen with the stress paradigm.
Journal ArticleDOI
Protecting‐Group‐Dependent Stability of Intersaccharide Bonds—Synthesis of a Fucosyl‐Chitobiose Glycopeptide
Horst Kunz,Carlo Unverzagt +1 more
Journal ArticleDOI
Dendritic and hyperbranched polyamides
TL;DR: In this paper, the synthesis and properties of dendritic and hyperbranched polyamides are discussed and examples of applications of these materials as rheology modifiers or as supports for the preparation of nanoparticles are presented.
References
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Journal ArticleDOI
The Use of Esters of N-Hydroxysuccinimide in Peptide Synthesis
Journal ArticleDOI
t-Butyl Esters of Amino Acids and Peptides and their Use in Peptide Synthesis1
Journal ArticleDOI
Zur Synthese des Glucagons, X. Darstellung der Sequenz 22–29
Erich Wünsch,Fritz Drees +1 more
TL;DR: In this paper, the geschutzte Teilsequenz 22-29 des Glucagons, wird auf zwei verschiedenen Wegen synthetisiert.