Journal ArticleDOI
Eine neue Methode zur Synthese von Peptiden: Aktivierung der Carboxylgruppe mit Dicyclohexylcarbodiimid unter Zusatz von 1‐Hydroxy‐benzotriazolen
Wolfgang König,Rolf Geiger +1 more
TLDR
In this article, the authors show that 1-Hydroxy-benzotriazol and 1-hydroxy-acetyl carbodiimid-methode eignen sich als Zusatze bei der Dicyclohexylcarbodiimids-Methode zur Synthese von Peptiden, verhindern die N-Acyl-harnstoffbildung and fuhren in hoher Ausbeute.Abstract:
1-Hydroxy-benzotriazol sowie verschiedene kernsubstituierte 1-Hydroxy-benzotriazole eignen sich als Zusatze bei der Dicyclohexylcarbodiimid-Methode zur Synthese von Peptiden. Ihr Einflus auf die Racemisierung bei Peptidsynthesen wurde unter Anwendung des gaschromatographischen Racemisierungstests von Weygand u. Mitarbb.2) untersucht. Die neuen Zusatze senken die Racemisierung, verhindern die N-Acyl-harnstoffbildung und fuhren in hoher Ausbeute zu sehr reinen Peptiden.read more
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Nonapeptide Analogues Containing (R)-3-Hydroxybutanoate and β-Homoalanine Oligomers: Synthesis and Binding Affinity to a Class I Major Histocompatibility Complex Protein
TL;DR: It is demonstrated that beta-amino acids can be incorporated in the sequence of viral T-cell epitopes without impairing MHC binding, which opens the door to the rational design of peptide-based vaccines and of nonnatural T-cells receptor antagonists aimed at blocking peptidic-specific T- cell responses in MHC-associated autoimmune diseases.
Journal ArticleDOI
Total synthesis of deglyco-bleomycin A2
Tomohisa Takita,Yoji Umezawa,Sei ichi Saito,Hajime Morishima,Hamao Umezawa,Yasuhiko Muraoka,Masanobu Suzuki,Masami Otsuka,Susumu Kobayashi,Masaji Ohno +9 more
TL;DR: Deglyco-bleomycin A2, the aglycon of bleomycin, has been synthesized for the first time in this paper, and it is shown that it can be used to synthesize degreco-Bleomycin.
Journal ArticleDOI
Preparation of N-hydroxyazoles by oxidation of azoles
Mikael Begtrup,Per Vedsø +1 more
TL;DR: In this article, Azoles without N-substituents are oxidized with per-acids or perborate to the corresponding N-hydroxy substituted azoles.
Journal ArticleDOI
Vitamin K-dependent carboxylation. Study of the hydrogen abstraction stereochemistry with gamma-fluoroglutamic acid-containing peptides.
TL;DR: Results reveal that the enzymatic hydrogen abstraction step is stereospecific and corresponds, in the gamma-fluoroglutamate case, to the elimination of the hydrogen equivalent to the pro-S hydrogen of glutamic acid.
Journal ArticleDOI
4‐(Dimethylamino)pyridine N‐oxide (DMAPO): An Effective Nucleophilic Catalyst in the Peptide Coupling Reaction with 2‐Methyl‐6‐nitrobenzoic Anhydride
TL;DR: Various carboxamides or peptides were synthesized from the corresponding carboxylic acids and amines or alpha-amino acids in high yields by the catalysis of 4-(dimethylamino)pyridine N-oxide (DMAPO) with 2-methyl-6-nitrobenzoic anhydride (MNBA).
References
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Journal ArticleDOI
The Use of Esters of N-Hydroxysuccinimide in Peptide Synthesis
Journal ArticleDOI
t-Butyl Esters of Amino Acids and Peptides and their Use in Peptide Synthesis1
Journal ArticleDOI
Zur Synthese des Glucagons, X. Darstellung der Sequenz 22–29
Erich Wünsch,Fritz Drees +1 more
TL;DR: In this paper, the geschutzte Teilsequenz 22-29 des Glucagons, wird auf zwei verschiedenen Wegen synthetisiert.