Journal ArticleDOI
Eine neue Methode zur Synthese von Peptiden: Aktivierung der Carboxylgruppe mit Dicyclohexylcarbodiimid unter Zusatz von 1‐Hydroxy‐benzotriazolen
Wolfgang König,Rolf Geiger +1 more
TLDR
In this article, the authors show that 1-Hydroxy-benzotriazol and 1-hydroxy-acetyl carbodiimid-methode eignen sich als Zusatze bei der Dicyclohexylcarbodiimids-Methode zur Synthese von Peptiden, verhindern die N-Acyl-harnstoffbildung and fuhren in hoher Ausbeute.Abstract:
1-Hydroxy-benzotriazol sowie verschiedene kernsubstituierte 1-Hydroxy-benzotriazole eignen sich als Zusatze bei der Dicyclohexylcarbodiimid-Methode zur Synthese von Peptiden. Ihr Einflus auf die Racemisierung bei Peptidsynthesen wurde unter Anwendung des gaschromatographischen Racemisierungstests von Weygand u. Mitarbb.2) untersucht. Die neuen Zusatze senken die Racemisierung, verhindern die N-Acyl-harnstoffbildung und fuhren in hoher Ausbeute zu sehr reinen Peptiden.read more
Citations
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Supramolecular hydrogel capsules based on PEG: a step toward degradable biomaterials with rational design.
Torsten Rossow,Sebastian Bayer,Ralf Albrecht,C. Christoph Tzschucke,Sebastian Seiffert,Sebastian Seiffert +5 more
TL;DR: Reversion of the supramolecular polymer cross-linking allows the microcapsules to be degraded at mild conditions with no effect on the viability of the encapsulated and released cells.
Journal ArticleDOI
Der Adamantyl‐(1)‐oxycarbonyl‐Rest als Schutzgruppe für die Guanidinofunktion des Arginins
Georg Jäger,Rolf Geiger +1 more
TL;DR: The 1-Adamantyloxycarbonyl Residue as Blocking Group for the Guanidino Function of Arginine as mentioned in this paper was introduced in high yield into the guanidino function by reaction of Nα-protected arginine with 1-adamantyl chloroformate.
Journal ArticleDOI
Heptanuclearity in nickel(II) chemistry: preparation, characterization, crystal structure and magnetic properties of [Ni7(OH)2(acac)8(btaO)4(H2O)2] (btaO−=the 1-hydroxybenzotriazolate ion)
Eleanna Diamantopoulou,Catherine P. Raptopoulou,Aris Terzis,Vassilis Tangoulis,Spyros P. Perlepes +4 more
TL;DR: In this paper, the structure of 4·MeCN·0.9H2O was determined by single-crystal X-ray crystallography, and the heptanuclear assembly was held together by two μ3 hydroxo ligands, two terminal H2O molecules, four chelating acac− groups, two μ2 acac+ groups, four acac-groups, two µ2 acAC− groups and two µ3 acac − groups.
Journal ArticleDOI
N-terminal myristylation of HBV preS1 domain enhances receptor recognition.
S. De Falco,Menotti Ruvo,Antonio Verdoliva,Angela Scarallo,Domenico Raimondo,Angela Raucci,Giorgio Fassina +6 more
TL;DR: HBV-receptor binding assays performed with plasma membranes preparations from the hepatocyte carcinoma cell line HepG2 clearly showed that the preS1[1-119] domain recognizes the HBV receptor, and confirmed that binding is occurring through the 21-47 region, suggesting that the conformational transitions induced in thePreS1 moiety by fatty acid post-translational modification are important for efficient attachment of viral particles to HBV receptors.
Journal ArticleDOI
Intermolecular stabilisation of the β-sheet conformation in dipeptides
TL;DR: Dipeptides are stabilised in the β-sheet conformation by three-point binding through hydrogen bonds to 3-aminopyrazole binding sites.
References
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Journal ArticleDOI
The Use of Esters of N-Hydroxysuccinimide in Peptide Synthesis
Journal ArticleDOI
t-Butyl Esters of Amino Acids and Peptides and their Use in Peptide Synthesis1
Journal ArticleDOI
Zur Synthese des Glucagons, X. Darstellung der Sequenz 22–29
Erich Wünsch,Fritz Drees +1 more
TL;DR: In this paper, the geschutzte Teilsequenz 22-29 des Glucagons, wird auf zwei verschiedenen Wegen synthetisiert.