Journal ArticleDOI
Eine neue Methode zur Synthese von Peptiden: Aktivierung der Carboxylgruppe mit Dicyclohexylcarbodiimid unter Zusatz von 1‐Hydroxy‐benzotriazolen
Wolfgang König,Rolf Geiger +1 more
TLDR
In this article, the authors show that 1-Hydroxy-benzotriazol and 1-hydroxy-acetyl carbodiimid-methode eignen sich als Zusatze bei der Dicyclohexylcarbodiimids-Methode zur Synthese von Peptiden, verhindern die N-Acyl-harnstoffbildung and fuhren in hoher Ausbeute.Abstract:
1-Hydroxy-benzotriazol sowie verschiedene kernsubstituierte 1-Hydroxy-benzotriazole eignen sich als Zusatze bei der Dicyclohexylcarbodiimid-Methode zur Synthese von Peptiden. Ihr Einflus auf die Racemisierung bei Peptidsynthesen wurde unter Anwendung des gaschromatographischen Racemisierungstests von Weygand u. Mitarbb.2) untersucht. Die neuen Zusatze senken die Racemisierung, verhindern die N-Acyl-harnstoffbildung und fuhren in hoher Ausbeute zu sehr reinen Peptiden.read more
Citations
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Strategies and methods for the attachment of amino acids and peptides to chiral [n]polynorbornane templates
TL;DR: A versatile synthesis of amino acid and peptide functionalised [n]polynorbornane scaffolds is described, which allow a range of topologies to be accessed and a number of regioselectively addressable linkage points to be accommodated.
Journal ArticleDOI
Tertiäres Phosphan/Hexachlorethan als Kondensationsreagenz für die Peptidsynthese
Rolf Apple,Lothar Willms +1 more
TL;DR: In this paper, the action of tertiary phosphane/hexachloroethane on N-protected amino acids and amino acid esters is found applicable for peptide synthesis and no difficulties are found when the side chains of serine, threonine, tyrosine, asparagine and glutamine are present.
Journal ArticleDOI
A new type of ligand derived from N-terminal protected dipeptides in enantioselective addition of phenylacetylene to aromatic ketones at room temperature
TL;DR: In this article, a ligand derived from N-terminal protected l -Phe-based dipeptides was found to be effective in catalyzing the enantioselective addition of phenylacetylene to aromatic ketones with up to 91% ee.
Journal ArticleDOI
Radioactive probes for adrenocorticotropic hormone receptors.
Klaus Hofmann,Hana Romovacek,Christine Stehle,Frances M. Finn,Aksel A. Bothner-By,P. K. Mishra +5 more
TL;DR: Three peptides are prepared that are equipotent with the standard ACTH1-24 as concerns their ability to stimulate steroidogenesis and cAMP formation in bovine adrenal cortical cells, and the HPLC profiles and amino acid analyses of the final products indicate that the materials are of a high degree of purity.
Journal ArticleDOI
Designed peptides for biomineral polymorph recognition: a case study for calcium carbonate
Timo Schüler,Jochen Renkel,Stephan Hobe,Moritz Susewind,Dorrit E. Jacob,Martin Panthöfer,Anja Hoffmann-Röder,Harald Paulsen,Wolfgang Tremel +8 more
TL;DR: An engineered heptapeptide is reported that can differentiate between the crystalline anhydrous polymorphs of calcium carbonate and contains the positively charged amino acid arginine as well as proline rather than the prototypical negatively charged aspartate or glutamate units.
References
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Journal ArticleDOI
The Use of Esters of N-Hydroxysuccinimide in Peptide Synthesis
Journal ArticleDOI
t-Butyl Esters of Amino Acids and Peptides and their Use in Peptide Synthesis1
Journal ArticleDOI
Zur Synthese des Glucagons, X. Darstellung der Sequenz 22–29
Erich Wünsch,Fritz Drees +1 more
TL;DR: In this paper, the geschutzte Teilsequenz 22-29 des Glucagons, wird auf zwei verschiedenen Wegen synthetisiert.