From neural development to cognition: unexpected roles for chromatin
TLDR
Interestingly, mutations in EZH2 and certain BAF complex components have roles in both neurodevelopmental disorders and cancer, and overlapping point mutations are suggesting functionally important residues and domains.Abstract:
Recent genome-sequencing studies in human neurodevelopmental and psychiatric disorders have revealed mutations in chromatin-modifying enzymes, such as chromatin remodellers and histone-modifying enzymes. Such studies are improving our understanding of the roles of these modifiers in human neurodevelopment, and this article discusses the emerging roles for several of these enzymes in development and disease.read more
Citations
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The Mendelian disorders of the epigenetic machinery
TL;DR: Two of the Mendelian disorders of the epigenetic machinery have shown post-natal rescue of markers of the neurological dysfunction with drugs that lead to histone deacetylase inhibition, indicating that some of these disorders may be treatable causes of intellectual disability.
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SWI/SNF Complex Prevents Lineage Reversion and Induces Temporal Patterning in Neural Stem Cells
Elif Eroglu,Thomas R Burkard,Yanrui Jiang,Nidhi Saini,Catarina C.F. Homem,Heinrich Reichert,Juergen A. Knoblich +6 more
TL;DR: It is shown that Osa induces a transcriptional program in the transit-amplifying population that initiates temporal patterning, limits self-renewal, and prevents dedifferentiation, and the Prdm protein Hamlet is identified as a key component of this program.
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The role of BAF (mSWI/SNF) complexes in mammalian neural development
Esther Y. Son,Gerald R. Crabtree +1 more
TL;DR: The BAF (mammalian SWI/SNF) complexes are a family of multi‐subunit ATP‐dependent chromatin remodelers that use ATP hydrolysis to alter chromatin structure that are essential for neural development, homeostasis, and plasticity.
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Epigenetic mechanisms in schizophrenia
TL;DR: Gene-scale mapping of DMA methylation, histone modifications and variants, and chromosomal loopings for promoter-enhancer interactions and other epigenetic determinants of genome organization and function are likely to provide important clues about mechanisms contributing to dysregulated expression of synaptic and metabolic genes in schizophrenia brain.
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Characterizing Protein–Protein Interactions Using Mass Spectrometry: Challenges and Opportunities
Arne H. Smits,Michiel Vermeulen +1 more
TL;DR: The need to miniaturize workflows to analyze protein interactions in biological and pathological contexts where sample amounts are limited is emphasized.
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