From neural development to cognition: unexpected roles for chromatin
TLDR
Interestingly, mutations in EZH2 and certain BAF complex components have roles in both neurodevelopmental disorders and cancer, and overlapping point mutations are suggesting functionally important residues and domains.Abstract:
Recent genome-sequencing studies in human neurodevelopmental and psychiatric disorders have revealed mutations in chromatin-modifying enzymes, such as chromatin remodellers and histone-modifying enzymes. Such studies are improving our understanding of the roles of these modifiers in human neurodevelopment, and this article discusses the emerging roles for several of these enzymes in development and disease.read more
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The splicing regulator PTBP1 controls the activity of the transcription factor Pbx1 during neuronal differentiation
Anthony J Linares,Chia-Ho Lin,Andrey Damianov,Katrina L. Adams,Bennett G. Novitch,Douglas L. Black +5 more
TL;DR: PTBP1 controls the activity of Pbx1 to suppress its neuronal transcriptional program prior to induction of NPC development and it is found that PTBP1 represses P bx1 exon 7 and the expression of the neuronal PbX1a isoform in ESCs.
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Actin-like 6A predicts poor prognosis of hepatocellular carcinoma and promotes metastasis and epithelial-mesenchymal transition.
Shuai Xiao,Rui-Min Chang,Ming-Yang Yang,Xiong Lei,Xiao Liu,Wen-Bin Gao,Jing-Lei Xiao,Lian-Yue Yang +7 more
TL;DR: It is found that ACTL6A plays an essential role in metastasis and EMT of HCC and is indicated as a prognostic biomarker candidate and a potential therapeutic target for HCC.
Journal ArticleDOI
Promoter Decommissioning by the NuRD Chromatin Remodeling Complex Triggers Synaptic Connectivity in the Mammalian Brain
Tomoko Yamada,Tomoko Yamada,Yue Bo Yang,Yue Bo Yang,Martin Hemberg,Toshimi Yoshida,Ha Young Cho,Ha Young Cho,J. Patrick Murphy,Diasynou Fioravante,Wade G. Regehr,Steven P. Gygi,Katia Georgopoulos,Azad Bonni,Azad Bonni +14 more
TL;DR: This work reports that depletion of the NuRD complex by in vivo RNAi and conditional knockout of the core NuRD subunit Chd4 profoundly impairs the establishment of granule neuron parallel fiber/Purkinje cell synapses in the rodent cerebellar cortex in vo.
Journal ArticleDOI
Exome sequencing for bipolar disorder points to roles of de novo loss-of-function and protein-altering mutations
Kataoka M,Kataoka M,Nana Matoba,Nana Matoba,Sawada T,An-a Kazuno,Mizuho Ishiwata,Kumiko Fujii,Kumiko Fujii,Koji Matsuo,Atsushi Takata,Tadafumi Kato +11 more
TL;DR: The results of exploratory analyses collectively point to the roles of de novo LOF and protein-altering mutations in the etiology of bipolar disorder and warrant further large-scale studies.
Journal ArticleDOI
Kinetic Analysis of npBAF to nBAF Switching Reveals Exchange of SS18 with CREST and Integration with Neural Developmental Pathways
Brett T. Staahl,Jiong Tang,Wei Wu,Alfred Xuyang Sun,Aaron D. Gitler,Andrew S. Yoo,Gerald R. Crabtree +6 more
TL;DR: The kinetics of neuron-specific BAF complex assembly in the formation of induced neurons from mouse embryonic stem cells, human fibroblasts, and normal mouse neural differentiation are defined and it is found that switching of chromatin remodeling mechanisms is highly correlated with a broad switch in the use of neurogenic transcription factors.
References
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