From neural development to cognition: unexpected roles for chromatin
TLDR
Interestingly, mutations in EZH2 and certain BAF complex components have roles in both neurodevelopmental disorders and cancer, and overlapping point mutations are suggesting functionally important residues and domains.Abstract:
Recent genome-sequencing studies in human neurodevelopmental and psychiatric disorders have revealed mutations in chromatin-modifying enzymes, such as chromatin remodellers and histone-modifying enzymes. Such studies are improving our understanding of the roles of these modifiers in human neurodevelopment, and this article discusses the emerging roles for several of these enzymes in development and disease.read more
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Transcription and FACT facilitate the restoration of replication-coupled chromatin assembly defects
Marta Barrientos-Moreno,Douglas Maya-Miles,Marina Murillo-Pineda,Sara Fontalva,Mónica Pérez-Alegre,Eloisa Andújar,Félix Prado +6 more
Dissertation
Mechanisms underlying the temporal and selective induction of Ptf1a target genes
TL;DR: BiFC analysis and ATAC-seq suggest that Ptf1a acts as a pioneer transcription factor to activate its target genes, and suggests that target gene activation by PTF1a is likely independent of chromatin accessibility.
Journal ArticleDOI
Identification of genes responsible for the social skill in the earthworm, Eudrilus eugeniae
Saranya Lathakumari,Subburathinam Balakrishnan,Audre Preena Maria Sundar Raj,Hiroshi Sugiyama,Ganesh Pandian Namasivayam,Sudhakar Sivasubramaniam +5 more
TL;DR: In this article , the authors harnessed the earthworm Eudrilus eugeniae as a model to understand the molecular depth of social ability using their behaviour of self-assemblage.
Journal ArticleDOI
Involvement of the H3.3 Histone Variant in the Epigenetic Regulation of Gene Expression in the Nervous System, in Both Physiological and Pathological Conditions
TL;DR: In this paper , the role of the H3.3 histone variant, with particular attention to its loading into chromatin in the mammalian nervous system, both in physiological and pathological conditions, is discussed.
Epigenetics: major regulators of embryonic neurogenesis
TL;DR: Recently, it is becoming increasingly clear that epigenetic regulation of cortical development occurs at multiple levels and that compre- hensive knowledge of this complex regulatory landscape is essential to delineating embryonic neurogenesis as mentioned in this paper.
References
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Translating the Histone Code
Thomas Jenuwein,C. David Allis +1 more
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Functions of DNA methylation: islands, start sites, gene bodies and beyond
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Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2.
Ruthie E. Amir,Ignatia B. Van den Veyver,Mimi Wan,Charles Q. Tran,Uta Francke,Huda Y. Zoghbi +5 more
TL;DR: This study reports the first disease-causing mutations in RTT and points to abnormal epigenetic regulation as the mechanism underlying the pathogenesis of RTT.
Journal ArticleDOI
Genome-wide maps of chromatin state in pluripotent and lineage-committed cells
Tarjei S. Mikkelsen,Manching Ku,Manching Ku,David B. Jaffe,Biju Issac,Biju Issac,Erez Lieberman Aiden,Erez Lieberman Aiden,Georgia Giannoukos,Pablo Alvarez,William Brockman,Tae Kyung Kim,Richard Koche,Richard Koche,Richard Koche,William Lee,Eric M. Mendenhall,Eric M. Mendenhall,Aisling O'Donovan,Aviva Presser,Carsten Russ,Xiaohui Xie,Alexander Meissner,Marius Wernig,Rudolf Jaenisch,Chad Nusbaum,Eric S. Lander,Eric S. Lander,Bradley E. Bernstein,Bradley E. Bernstein +29 more
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