Interferon-stimulated genes and their antiviral effector functions.
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TLDR
Some of the most potent antiviral effectors reinforce the system by further inducing IFN or ISGs, suggesting that some viruses may have evolved to co-opt IFN effectors for a survival advantage.About:
This article is published in Current Opinion in Virology.The article was published on 2011-12-01 and is currently open access. It has received 1068 citations till now. The article focuses on the topics: Interferon type I & Interferon.read more
Citations
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Journal ArticleDOI
Mitochondrial DNA Stress Primes the Antiviral Innate Immune Response
A. Phillip West,William Khoury-Hanold,Matthew M. Staron,Michal Caspi Tal,Cristiana M. Pineda,Sabine Lang,Megan Bestwick,Brett A. Duguay,Nuno Raimundo,Donna A. MacDuff,Susan M. Kaech,James R. Smiley,Robert E. Means,Akiko Iwasaki,Gerald S. Shadel +14 more
TL;DR: It is shown that moderate mtDNA stress elicited by TFAM deficiency engages cytosolic antiviral signalling to enhance the expression of a subset of interferon-stimulated genes, and it is suggested that cellular monitoring of mtDNA homeostasis cooperates with canonical virus sensing mechanisms to fully engage antiviral innate immunity.
Journal ArticleDOI
Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity
John W. Schoggins,Donna A. MacDuff,Naoko Imanaka,Maria D. Gainey,Bimmi Shrestha,Jennifer L. Eitson,Katrina B. Mar,R. Blake Richardson,Alexander V. Ratushny,Vladimir Litvak,Rea Dabelic,Balaji Manicassamy,John D. Aitchison,Alan Aderem,Richard M. Elliott,Adolfo García-Sastre,Vincent R. Racaniello,Eric J. Snijder,Wayne M. Yokoyama,Michael S. Diamond,Herbert W. Virgin,Charles M. Rice +21 more
TL;DR: Comparative analysis reveals that the screened ISGs target positive-sense single-stranded RNA viruses more effectively than negative-sensesingle-strander RNA viruses.
Journal ArticleDOI
Type I and Type III Interferons - Induction, Signaling, Evasion, and Application to Combat COVID-19.
TL;DR: The recent progress in the understanding of both type I and type III IFN-mediated innate antiviral responses against human coronaviruses is described and the potential use of IFNs as a treatment strategy for COVID-19 is discussed.
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Persistent LCMV Infection Is Controlled by Blockade of Type I Interferon Signaling
John R. Teijaro,Cherie T. Ng,Andrew M. Lee,Brian M. Sullivan,Kathleen C. F. Sheehan,Megan J. Welch,Robert D. Schreiber,Juan Carlos de la Torre,Michael B. A. Oldstone +8 more
TL;DR: A direct causal link between IFN-I signaling, immune activation, negative immune regulator expression, lymphoid tissue disorganization, and virus persistence is demonstrated and the results suggest that therapies targeting IFn-I may help control persistent virus infections.
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The broad-spectrum antiviral functions of IFIT and IFITM proteins
TL;DR: This Review focuses on recent advances in identifying the unique mechanisms of action of IFIT and IFITM proteins, which explain their broad-spectrum activity against the replication, spread and pathogenesis of a range of human viruses.
References
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Pattern Recognition Receptors and Inflammation
Osamu Takeuchi,Shizuo Akira +1 more
TL;DR: The role of PRRs, their signaling pathways, and how they control inflammatory responses are discussed.
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Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
Hiroki Kato,Osamu Takeuchi,Shintaro Sato,Mitsutoshi Yoneyama,Masahiro Yamamoto,Kosuke Matsui,Satoshi Uematsu,Andreas Jung,Taro Kawai,Ken Ishii,Osamu Yamaguchi,Kinya Otsu,Tohru Tsujimura,Chang-Sung Koh,Caetano Reis e Sousa,Yoshiharu Matsuura,Takashi Fujita,Shizuo Akira +17 more
TL;DR: It is found that RIG-I is essential for the production of interferons in response to RNA viruses including paramyxoviruses, influenza virus and Japanese encephalitis virus, whereas MDA5 is critical for picornavirus detection.
Journal ArticleDOI
IRF-7 is the master regulator of type-I interferon-dependent immune responses
Kenya Honda,Hideyuki Yanai,Hideo Negishi,Masataka Asagiri,Mitsuharu Sato,Tatsuaki Mizutani,Naoya Shimada,Yusuke Ohba,Yusuke Ohba,Akinori Takaoka,Nobuaki Yoshida,Tadatsugu Taniguchi +11 more
TL;DR: It is shown that mice deficient in the Irf7 gene are more vulnerable than Myd88-/- mice to viral infection, and this correlates with a marked decrease in serum IFN levels, indicating the importance of the IRF-7-dependent induction of systemic IFN responses for innate antiviral immunity.
Journal ArticleDOI
Interferon-inducible antiviral effectors
TL;DR: This Review discusses four main effector pathways of the IFN-mediated antiviral response: the Mx GTPase pathway, the 2′,5′-oligoadenylate-synthetase-directed ribonuclease L pathways, the protein kinase R pathway and the ISG15 ubiquitin-like pathway.
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A diverse range of gene products are effectors of the type I interferon antiviral response
John W. Schoggins,Sam J. Wilson,Maryline Panis,Mary Murphy,Christopher T. Jones,Paul D. Bieniasz,Charles M. Rice +6 more
TL;DR: It is shown that different viruses are targeted by unique sets of ISGs, and that each viral species is susceptible to multiple antiviral genes, which together encompass a range of inhibitory activities.